Involvement of orexin-A and neuropeptide Y in the antidepressant-like effect of kososan.

在本研究中，我们的结果提出了一种可能性，即从食欲素到神经肽Y （NPY）系统的信号通路在科索沃的抗抑郁作用中起着至关重要的作用。这些发现表明，科索沃的抗抑郁样作用与食欲能和NPYergic网络的调节密切相关，并且我们已经部分揭示了科索沃和抗抑郁药的抗抑郁样作用机制的潜在差异。这些发现可能有助于开发具有针对食欲能和NPYergic系统的新型作用机制的抗抑郁药。

In the present study, our results raise the possibility that signal pathways from orexin to neuropeptide Y (NPY) system play crucial roles in an antidepressant-like effect of kososan. These findings suggest that the antidepressant-like effect of kososan is strongly associated with the regulation of orexinergic and NPYergic network, and we have partly uncovered the potential differences in the mechanisms underlying the antidepressant-like effects of kososan and of antidepressants. These findings may contribute to the development of antidepressants with novel mechanisms of action targeting the orexinergic and NPYergic system.