Role of orexinergic system in the mechanism underlying an antidepressant-like effect of kososan

在本研究中，我们首次发现增食欲素A(OX-A)增加了海马区培养细胞神经肽Y(NPY)的产生。此外，我们之前的研究表明，葛根多糖的抗抑郁作用在某种程度上与OX-A和NPY的调节有关。因此，目前的发现强调了在海马体中OX-A和NPY之间存在网络。这可能有助于我们理解牛膝多糖抗抑郁作用的机制。

In the present study, we first found orexin A (OX-A) increases the production of neuropeptide Y (NPY) from hippocampal cultured cells. Also, our previous study has shown that an antidepressant-like effect of kososan is linked in some way to the regulation of OX-A and NPY. Thus, the present findings highlight the presence of a network between OX-A and NPY in the hippocampus. This may be useful for our understanding the mechanism underlying kososan’s antidepressant-like property.