Study of the differentiation and the regulation of naive T cell in tumor-bearing host

我们检测了接受初始T细胞过继转移治疗的小鼠淋巴细胞表型的变化。尽管可以诱导调节性T细胞(Treg)的免疫抑制细胞因子，如转化生长因子-β，在荷瘤小鼠中被认为是丰富的，但我们没有发现在初始T细胞过继转移治疗的荷瘤小鼠中Treg的数量增加。此外，在小鼠模型中，我们发现联合热疗可以增强幼稚T细胞过继转移治疗的抗肿瘤活性。目前还不能建立一种有效的培养程序来获得原始T细胞，这是未来的任务。

We examined changes in the phenotype of lymphocyte in mice which were treated with naive T cells adoptive transfer. Although immunosuppressive cytokines such as TGF-beta, which could induce regulatory T cells (Treg), are thought to be abundant in tumor-bearing mice, we did not find the increase of Treg population in tumor-bearing mice treated with naive T cells adoptive transfer. Additionally, we found that combination of hyperthermia enhanced anti-tumor activity of naive T cell adoptive transfer therapy in mice model. An effective culture procedure to obtain the naive T cells cannot be established yet, and it is future task.