The role of TLR4 in the pathogenesis of renal fibrosis and the possible effect of blocking TLR4 signal

TLR4在肾纤维化发病机制中的作用及阻断TLR4信号的可能作用

• 批准号: 21790807
• 负责人: MIYATA Hitomi
• 金额: $ 2.66万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790807/
• 关键词: 腎臓病; 腎線維化; TLR4; IVFM

We hypothesized that TLR4 might be involved in the development of UO induced renal injury, which has been reported that it plays a role in the pathogenesis of liver fibrosis. The current study was performed using wild type, deficient, (TLR4 knock out mice) and HEJ(TLR4 defective) mice which were inducted UUO. We compared these groups using parameters such as microcirculation, histological and molecular biological methods The results suggested that TLR4 would be related with the early phase of renal fibrosis induced by UO.

我们推测TLR4可能参与了UO诱导的肾损伤的发生，这已被报道在肝纤维化的发病机制中起作用。本研究使用诱导UUO的野生型、缺陷型（TLR4敲除小鼠）和HEJ（TLR4缺陷型）小鼠进行。通过微循环、组织学和分子生物学等指标对各组进行比较，结果提示TLR 4可能与UO所致的早期肾纤维化有关。

项目成果

The possible effect of Toll-like receptor 4 on the early stage of renal fibrosis

Toll样受体4对早期肾纤维化的可能作用

• 发表时间: 2010
• 作者: Hitomi Miyata-Watanabe;April Xu-Holland;Atsushi Fukatsu;Antony Wheatley
• 通讯作者: Antony Wheatley

HEMODYNAMIC AND STRUCTUAL CHANGES TO THE RENAL MICROCIRCULATION FOLLOWING UNILATERAL URETERAL OBSTRUCTION(UUO) IN THE MOUSE

小鼠单侧输尿管梗阻（UUO）后肾微循环的血流动力学和结构变化

• 发表时间: 2009
• 作者: Hitomi Watanabe;Atsushi Fukatsu;Rahul Das Antony Wheatley;宮田仁美
• 通讯作者: 宮田仁美

生体蛍光顕微鏡による水腎症マウスにおける血行動態ならびに構造的変化の観察

活体荧光显微镜观察肾积水小鼠血流动力学和结构变化

• 发表时间: 2009
• 作者: 渡部仁美;深津敦司;Das Rahul;Antony Wheatley
• 通讯作者: Antony Wheatley

生体蛍光顕微鏡による水腎症マウスにおける血行動態的ならびに構造的変化の観察

活体荧光显微镜观察肾积水小鼠血流动力学和结构变化

• 发表时间: 2009
• 作者: Hitomi Miyata-Watanabe;April Xu-Holland;Atsushi Fukatsu;Antony Wheatley;Hitomi Miyata-Watanabe;宮田仁美
• 通讯作者: 宮田仁美

Hemodynamic and structural changes to the renal microcirculation following unilateral ureteral obstruction(UUO) in the mouse

小鼠单侧输尿管梗阻（UUO）后肾微循环的血流动力学和结构变化

• 发表时间: 2009
• 作者: Hitomi Watanabe;Atsushi Fukatsu;Rahul Das Antony Wheatley
• 通讯作者: Rahul Das Antony Wheatley