The role of Janus tyrosine kinase(JAK) signal transducer and activator of transcription(STAT) and suppressor of cytokine signaling (SOCS) pathway in the renal interstitial fibrosis after unilateral ureteral obstruction

Janus酪氨酸激酶(JAK)信号转导和转录激活子(STAT)及细胞因子信号抑制(SOCS)通路在单侧输尿管梗阻后肾间质纤维化中的作用

• 批准号: 21790826
• 负责人: KOIKE Kiyomi
• 金额: $ 2.58万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790826/
• 关键词: 腎線維化; JAK/STAT/SOCS; 片側尿管結紮モデル; JAK; STAT; SOCS

Protective role of JAK/STAT signaling against renal fibrosis in mice with unilateral ureteral obstructionJAK/STAT system is an essential intracellular signaling pathway of various cytokines and stimuli that could regulate a variety of inflammatory reactions, proliferation, and differentiation. SOCS work as a negative feedback pathway of this system. JAK/STAT/SOCS system may play an important role in renal responses. To clarify how JAK/STAT/SOCS system was involved in renal fibrosis, unilateral ureteral obstruction (UUO) was induced in BALB/c or SOCS3 heterozygous knockout (SOCS3+/-) mice in the presence or absence of JAK inhibitor-incorporated nanoparticle (pyridine6-PGLA). Our present study suggests that JAK/STAT3 signaling may play an important role in repair process of renal fibrosis in UUO partly via activation of MMP-2.

JAK/STAT信号通路对单侧输尿管梗阻小鼠肾纤维化的保护作用JAK/STAT系统是一条重要的细胞内信号通路，参与多种细胞因子和刺激物的调节，参与多种炎症反应、增殖和分化。SOCS作为该系统的负反馈通路发挥作用。JAK/STAT/SOCS系统可能在肾脏反应中起重要作用。为了阐明JAK/STAT/SOCS系统如何参与肾纤维化，在存在或不存在JAK标记物掺入的纳米颗粒（吡啶6-PGLA）的情况下，在BALB/c或SOCS 3杂合敲除（SOCS 3 +/-）小鼠中诱导单侧输尿管梗阻（UUO）。本研究提示JAK/STAT 3信号通路可能通过激活MMP-2在UUO肾纤维化修复过程中发挥重要作用。

项目成果

腎線維化におけるJAK/STAT/SOCSの役割

JAK/STAT/SOCS 在肾纤维化中的作用

• 发表时间: 2009
• 作者: Seiji Ueda;Sho-ichi Yamagishi;Hideo Yasukawa;Yusuke Kaida;Kei Fukami;Akihiko Yoshimura;Seiya Okuda;小池清美;小池清美上田誠二安川秀雄深水圭奥田誠也
• 通讯作者: 小池清美上田誠二安川秀雄深水圭奥田誠也

A New Vasculitis Activity Score for Predicting Death in Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Patients

• DOI: 10.1159/000334357
• 发表时间: 2012-01-01
• 期刊: AMERICAN JOURNAL OF NEPHROLOGY
• 影响因子: 4.2
• 作者: Koike, Kiyomi;Fukami, Kei;Okuda, Seiya
• 通讯作者: Okuda, Seiya

Experimental diabetic nephropathy is accelerated in matrix metalloproteinase-2 knockout mice.

• DOI: 10.1093/ndt/gfs387
• 发表时间: 2013
• 期刊: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
• 作者: Y. Takamiya;K. Fukami;S. Yamagishi;Y. Kaida;Yosuke Nakayama;Nana Obara;Ryuji Iwatani;Ryotaro Ando;Kiyomi Koike;T. Matsui;Yuri Nishino;S. Ueda;M. Cooper;S. Okuda

Interstitial Foxp3-positive T cells may predict renal survival in patients with myeroperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.

间质性 Foxp3 阳性 T 细胞可以预测 Myeroperodase 抗中性粒细胞胞质抗体相关性肾小球肾炎患者的肾脏存活率。

• 发表时间: 2010
• 期刊: Clin Exp Pharmacol Physiol.
• 作者: Yoshimura J;Fukami K;Koike K;Nagano M;Matsumoto T;Iwatani R;Kusumoto T;Hazama T;Ueda S;Adachi H;Hirai Y;Takasu K;Ohshima K;Yamagishi S;Okuda S.
• 通讯作者: Okuda S.

Case report; a case of acute kidney injury due to intravenous zoledronic acid hydrate, improved with bortezomib plus dexamethazone therapy in a patient with multiple myeloma

案例报告;

• 发表时间: 2011
• 期刊: Nihon Naika Gakkai Zasshi
• 作者: Koike K;Morishige S;Fukami K;Taguchi K;Yakushiji K;Okamura T;Okuda S.
• 通讯作者: Okuda S.