Expression regulation of basement membrane proteins by transcription factor of epithelial to mesenchymal transition

上皮间质转化转录因子对基底膜蛋白表达的调控

• 批准号: 21791055
• 负责人: NAKAJIMA Koji
• 金额: $ 2.75万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791055/
• 关键词: 遺伝子; シグナル伝達; 発現制御; 転写因子

Recent studies show that TGF-β is a key cytokine of EMT and zinc-finger transcription factor Snail also is a master transcription factor of EMT. Our group has been investigating on molecular mechanisms of expression regulation of basement membrane proteins and examining promoter analysis of BBAG1 and type VII collagen genes. The purpose of this study is to clarify how transcription factor Snail induced by TGF-β modulate expression of basement membrane proteins. The results showed that TGF-β induced expression of basement membrane proteins, resulting in suppression of EMT. Furthermore, transcription factor Snail played an important role in this phenomenon.

最近的研究表明，转化生长因子-β是子宫内膜癌的关键细胞因子，锌指转录因子Snail也是子宫内膜癌的主要转录因子。本课题组一直在研究基底膜蛋白表达调控的分子机制，并检测BBAG1和III型胶原基因的启动子分析。本研究旨在阐明转化生长因子β诱导的转录因子Snail对基底膜蛋白表达的调控作用。结果表明，转化生长因子-β可诱导基底膜蛋白的表达，从而抑制内皮细胞转化。此外，转录因子Snail在这一现象中发挥了重要作用。

项目成果

Multiple eruptive dermatofibromas associated with Hashimoto's thyroiditis and myasthenia gravis

与桥本甲状腺炎和重症肌无力相关的多发性发疹性皮肤纤维瘤

• DOI: 10.1684/ejd.2010.0981
• 发表时间: 2010
• 期刊: EUR J Dermatol
• 影响因子: 2.5
• 作者: Kimura Y;Kaneko T;Akasaka E;Nakajima K;Aizu T;Nakano H;Sawamura D
• 通讯作者: Sawamura D

A case of zosteriform metastatic skin cancer.

带状疱疹样转移性皮肤癌一例。

• 发表时间: 2008
• 期刊: Clin Exp Dermatol 33
• 作者: Minakawa S;Nakajima K;Aizu T;Nomura K;Kaimori M.
• 通讯作者: Kaimori M.

A linear basal cell carcinoma undergoing spontaneous regression.

正在自发消退的线性基底细胞癌。

• 发表时间: 2009
• 期刊: Clin Exp Dermatol 34
• 作者: Takiyoshi N;Nakano H;Kaneko T;Aizu T;Nakajima K;Akasaka E;Rokunohe D;Sawamura D.
• 通讯作者: Sawamura D.

Papillon-Lefevre syndrome and malignant melanoma : a high incidence of melanoma development in Japanese palmoplantar keratoderma patients.

Papillon-Lefevre 综合征和恶性黑色素瘤：日本掌跖角化症患者黑色素瘤的发生率很高。

• 发表时间: 2008
• 期刊: Dermatology 217
• 作者: Nakajima K;Nakano H;Takiyoshi N;Rokunohe A;Ikenaga S;Aizu T;Kaneko T;Mitsuhashi Y;Sawamura D.
• 通讯作者: Sawamura D.

Dermascopy of eccrine poroma with calcification.

皮肤镜检查伴有钙化的小汗腺孔瘤。

• 发表时间: 2009
• 期刊: J Dermatol Case Rep 3
• 作者: Nishikawa Y;Kaneko T;Kakiyoshi N;Aizu T;Nakajima K;Matsuzaki Y;Nakano H;Sawamura D.
• 通讯作者: Sawamura D.