Expression regulation of basement membrane proteins by transcription factor of epithelial to mesenchymal transition

最近的研究表明，转化生长因子-β是子宫内膜癌的关键细胞因子，锌指转录因子Snail也是子宫内膜癌的主要转录因子。本课题组一直在研究基底膜蛋白表达调控的分子机制，并检测BBAG1和III型胶原基因的启动子分析。本研究旨在阐明转化生长因子β诱导的转录因子Snail对基底膜蛋白表达的调控作用。结果表明，转化生长因子-β可诱导基底膜蛋白的表达，从而抑制内皮细胞转化。此外，转录因子Snail在这一现象中发挥了重要作用。

Recent studies show that TGF-β is a key cytokine of EMT and zinc-finger transcription factor Snail also is a master transcription factor of EMT. Our group has been investigating on molecular mechanisms of expression regulation of basement membrane proteins and examining promoter analysis of BBAG1 and type VII collagen genes. The purpose of this study is to clarify how transcription factor Snail induced by TGF-β modulate expression of basement membrane proteins. The results showed that TGF-β induced expression of basement membrane proteins, resulting in suppression of EMT. Furthermore, transcription factor Snail played an important role in this phenomenon.