Elucidation of keratinocyte differentiation and proliferation by splicing of transcritption factor.

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Skn-1, a member of the POU domain protein family, appears to be expressed predominantly in epidermal keratinocytes and is thought to play a critical role in keratinocyte differentiation and proliferation. Since Transcription factors are translated in the cytoplasm and transferred to the nucleus, study of nuclear transfer mechanism of their transcription factors is important. Recently, some studies reported that nuclear transfer of transcription factor is regulated in tissue or cell specific manners. However, nuclear transfer of transcription factor Skn-1 has not elucidated yet. In this study, we examined the mechanisms involved in the nuclear localization of Skn-1a to clarify involvement of Skn-1 nuclear transfer in keratinocyte differentiation and proliferation. The results showed that Skn-1 nuclear transfer may be related with keratinocyte differentiation and proliferation.