Elucidation of keratinocyte differentiation and proliferation by splicing of transcritption factor.

通过转录因子的剪接阐明角质形成细胞的分化和增殖。

• 批准号: 23791247
• 负责人: NAKAJIMA Koji
• 金额: $ 2.75万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791247/
• 关键词: 表皮細胞; 転写因子; 分化; 角化; 増殖

Skn-1, a member of the POU domain protein family, appears to be expressed predominantly in epidermal keratinocytes and is thought to play a critical role in keratinocyte differentiation and proliferation. Since Transcription factors are translated in the cytoplasm and transferred to the nucleus, study of nuclear transfer mechanism of their transcription factors is important. Recently, some studies reported that nuclear transfer of transcription factor is regulated in tissue or cell specific manners. However, nuclear transfer of transcription factor Skn-1 has not elucidated yet. In this study, we examined the mechanisms involved in the nuclear localization of Skn-1a to clarify involvement of Skn-1 nuclear transfer in keratinocyte differentiation and proliferation. The results showed that Skn-1 nuclear transfer may be related with keratinocyte differentiation and proliferation.

Skn-1是POU结构域蛋白家族的成员，似乎主要在表皮角质形成细胞中表达，并且被认为在角质形成细胞分化和增殖中起关键作用。由于转录因子是在细胞质中翻译并转移到细胞核的，因此研究其核转移机制具有重要意义。近年来，有研究报道转录因子的核转移是以组织或细胞特异性的方式进行调控的。然而，核转移转录因子Skn-1尚未阐明。在这项研究中，我们研究了Skn-1a的核定位的机制，以澄清参与Skn-1核转移角质形成细胞的分化和增殖。结果表明，Skn-1核移植可能与角质形成细胞的分化和增殖有关。

项目成果

Angiolymphoid hyperplasia with eosinophilia in infancy.

婴儿期血管淋巴样增生伴嗜酸性粒细胞增多。

• DOI: 10.1111/j.1346-8138.2012.01578.x
• 发表时间: 2012
• 期刊: J Dermatol.
• 作者: Ashida A;Kiniwa Y;Kobayashi A;Matsumoto K;Okuyama R.;Korekawa A
• 通讯作者: Korekawa A

膝窩郭清を施行した悪性黒色腫の1例

恶性黑色素瘤腘窝切除术一例

• 发表时间: 2011
• 作者: 中島康爾;金子高英;福井智久;西川陽平;中野 創;澤村大輔;竹本啓伸
• 通讯作者: 竹本啓伸

Buschke-Ollendorff syndrome associated with hypertrophic scar formation : a possible role for LEMD3 mutation

Buschke-Ollendorff 综合征与增生性疤痕形成相关：LEMD3 突变的可能作用

• DOI: 10.1111/j.1365-2133.2011.10691.x
• 发表时间: 2012
• 期刊: Br J Dermatol
• 作者: Korekawa A;Nakano H;Toyomaki Y;Takiyoshi N;Rokunohe D;Akasaka E;Nakajima K;Sawamura D
• 通讯作者: Sawamura D

Follicular mucinosis associated with radiation therapy

与放射治疗相关的滤泡粘蛋白沉积症

• DOI: 10.1111/j.1346-8138.2010.01187.x
• 发表时间: 2011
• 期刊: J Dermatol
• 影响因子: 3.1
• 作者: Akasaka E;Nakano H;Nakano A;Toyomaki Y;Takiyoshi N;Rokunohe D;Nishikawa Y;Korekawa A;Matsuzaki Y;Mitsuhashi Y;Sawamura D;Takeda H
• 通讯作者: Takeda H

Late-onset, Eruptive Syringoma in an Elderly Man : Correlation with Carbamazepine

老年人迟发性爆发性汗管瘤：与卡马西平的相关性

• DOI: 10.2340/00015555-1156
• 发表时间: 2012
• 期刊: Acta Derm Venereol
• 作者: Korekawa;Matsuzaki Y;et al.
• 通讯作者: et al.