PET study of dopamine receptor and psychiatric symptoms in patients with temporal epilepsy

颞叶癫痫患者多巴胺受体与精神症状的PET研究

• 批准号: 21791150
• 负责人: ICHIMIYA Tetsuya
• 金额: $ 2.75万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791150/
• 关键词: PET; ドパミンD2; 側頭葉てんかん; ドパミンD2受容体; FLB 457; SPM

Nine patients with left temporal lobe epilepsy and age-matched 14 healthy control subjects participated in this study. Binding potential of dopamine D2 receptors were examined using positron emission tomography. Parametric images of binding potentials were created and compared between groups. Binding potentials in the left temporal lobe, left inferior temporal lobe, left fusiform gyrus were decreased in patients compared to control subject. This could indicate decreased dopamine D2 neurotransmission in the ipsilateral temporal lobe.

这项研究参与了9名患有左颞叶癫痫患者和年龄匹配的14名健康对照组患者。使用正电子发射断层扫描检查多巴胺D2受体的结合潜力。创建了结合势的参数图像，并在组之间进行了比较。与对照组相比，患者的左颞叶中的结合电势，左下颞叶，左梭状回的质量降低。这可能表明在同侧颞叶中多巴胺D2神经传递降低。

项目成果

精神科臨床評価検査法マニュアル

精神病学临床评估测试方法手册

• 发表时间: 2010
• 作者: Toda S;Sakai A;Ikeda Y;Sakamoto A;Suzuki H.;一宮哲哉
• 通讯作者: 一宮哲哉

精神科臨床評価検査法マニュアル〔改訂版〕

精神科临床评估测试方法手册[修订版]

• 发表时间: 2010
• 作者: Kobayashi K;Ikeda Y;Sakai A;Yamasaki N;Haneda E;Miyakawa T;Suzuki H.;「臨床精神医学」編集委員会(編集)一宮哲哉(分担執筆)
• 通讯作者: 「臨床精神医学」編集委員会(編集)一宮哲哉(分担執筆)