Design of ^<99m>Tc-labled compound for diagnosis of metastatic tumor in bone

病变骨中血管通透性的增加表明，<99m>具有更高分子尺寸和羟基磷灰石结合的13 Tc标记的化合物将有助于检测病变骨。由于<99m>~（13）Tc标记的寡聚天冬氨酸比~（13）Tc-亚甲基二膦酸盐（~（13）Tc-MDP）具有更大的分子尺寸和更高的羟基磷灰石结合率<99m><99m>，为了评价~（13）Tc标记的寡聚天冬氨酸的分子设计<999m>，比较了~（13）<99m>Tc-标记的寡聚天冬氨酸和~（13）Tc-MDP在大鼠骨转移瘤中的蓄积<99m>。标记寡聚天冬氨酸的肿瘤与正常区域的比值<99m>高于标记<99m>MDP的肿瘤与正常区域的比值。这些结果表明，本分子设计将是有用的骨转移瘤的形象。

Increased permeability of blood vessels in diseased bone suggested that ^<99m>Tc-labeled compound of higher molecular size and hydroxyapatite binding would be useful to detect the diseased bone. Since ^<99m>Tc-labeled oligo-aspartic acid showed higher molecular size and higher hydroxyapatite binding than those of ^<99m>Tc-methylenediphosphonate (^<99m>Tc-MDP), to evaluate the molecular design of ^<999m>Tc-labeled oligo-aspartic acid, the accumulation of ^<99m>Tc-labeled oligo-aspartic acid in bone metastatic tumor of rat was compared with ^<99m>Tc-MDP. The tumor to normal region ratios of ^<99m>Tc-labeled oligo-aspartic acids were higher than those of ^<99m>Tc-MDP. These results suggested that the present molecular design would be useful to image bone metastatic tumor.