Design of ^<99m>Tc-labled compound for diagnosis of metastatic tumor in bone

病变骨血管通透性增加提示^<99m> tc标记的高分子量化合物与羟基磷灰石结合可用于病变骨的检测。由于^<99m> tc标记的低聚天冬氨酸比^<99m> tc -亚二膦酸盐（^<99m>Tc-MDP）具有更高的分子大小和更高的羟基磷灰石结合性，为了评价^<999m> tc标记的低聚天冬氨酸的分子设计，我们比较^<99m> tc标记的低聚天冬氨酸在大鼠骨转移瘤中的积累情况。^<99m> tc标记的低聚天冬氨酸与正常区比值高于^<99m>Tc-MDP标记的低聚天冬氨酸与正常区比值。这些结果表明，这种分子设计将有助于骨转移瘤的成像。

Increased permeability of blood vessels in diseased bone suggested that ^<99m>Tc-labeled compound of higher molecular size and hydroxyapatite binding would be useful to detect the diseased bone. Since ^<99m>Tc-labeled oligo-aspartic acid showed higher molecular size and higher hydroxyapatite binding than those of ^<99m>Tc-methylenediphosphonate (^<99m>Tc-MDP), to evaluate the molecular design of ^<999m>Tc-labeled oligo-aspartic acid, the accumulation of ^<99m>Tc-labeled oligo-aspartic acid in bone metastatic tumor of rat was compared with ^<99m>Tc-MDP. The tumor to normal region ratios of ^<99m>Tc-labeled oligo-aspartic acids were higher than those of ^<99m>Tc-MDP. These results suggested that the present molecular design would be useful to image bone metastatic tumor.