Design of ^<99m>Tc-labled compound for diagnosis of metastatic tumor in bone

病变骨内血管通透性增加，提示具有较大分子尺寸和羟基磷灰石结合力的~(99m)Tc标记化合物可用于病变骨的检测。由于~&lt；99m&gt；Tc标记的寡天冬氨酸显示出比^&lt；99m&gt；Tc-亚甲基二磷酸(^&lt；99m&gt；Tc-MDP)更大的分子尺寸和更高的羟基磷灰石结合力，为了评价^&lt；999m&gt；Tc标记的寡天冬氨酸的分子设计，比较了^&lt；99m&gt；Tc标记的寡天冬氨酸在大鼠骨转移瘤中的蓄积。~(99)m&GT；~(99)Tc标记的寡天冬氨酸的肿瘤与正常组织的比值高于~(&)lt；~(99m)GT；~(99)MDP。这些结果表明，目前的分子设计将有助于骨转移瘤的成像。

Increased permeability of blood vessels in diseased bone suggested that ^<99m>Tc-labeled compound of higher molecular size and hydroxyapatite binding would be useful to detect the diseased bone. Since ^<99m>Tc-labeled oligo-aspartic acid showed higher molecular size and higher hydroxyapatite binding than those of ^<99m>Tc-methylenediphosphonate (^<99m>Tc-MDP), to evaluate the molecular design of ^<999m>Tc-labeled oligo-aspartic acid, the accumulation of ^<99m>Tc-labeled oligo-aspartic acid in bone metastatic tumor of rat was compared with ^<99m>Tc-MDP. The tumor to normal region ratios of ^<99m>Tc-labeled oligo-aspartic acids were higher than those of ^<99m>Tc-MDP. These results suggested that the present molecular design would be useful to image bone metastatic tumor.