The examination of myocardial oxidative stress during cardiac surgery evaluated by oxidative bilirubin.

器官血流减少会导致组织的氧气和能量供应不足，导致心绞痛和心肌梗死等坏死。恢复血流和复氧可改善缺血心肌的新陈代谢，从而挽救心脏。同时，对缺血组织的再灌流也会造成缺血/再灌注损伤。活性氧(ROS)对组织的损伤被认为是缺血再灌注损伤的机制之一。在这项研究中，我们使用氧化胆红素和抗氧化剂成分，来研究氧化应激动力学和机制。

Reduced organ blood flow causes deficient oxygen and energy supply to the tissue, resulting in necrosis such as angina pectoris and myocardial infarction. Restoring blood flow and re-oxygenation improves metabolism in the ischemic myocardium, thus salvaging the heart. At the same time, reperfusion to the ischemic tissue can also cause ischemia/ reperfusion injury. Tissue damage from reactive oxygen species(ROS) has been suggested as a mechanism of ischemia reperfusion injury. In this study, we used oxidative bilirubin with an antioxidant component, to investigate oxidative stress dynamics and mechanisms.