Effects of general anesthetics on glucose metabolism in fed rats with hemorrhagic shock and ischemia/reperfusion

全身麻醉对失血性休克缺血再灌注大鼠糖代谢的影响

• 批准号: 21791437
• 负责人: KITAMURA Takayuki
• 金额: $ 2.83万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791437/
• 关键词: 糖代謝; 全身麻酔; 嫌気的代謝; 出血性ショック; 虚血再灌流

When compared to sevoflurane anesthesia, propofol anesthesia enhances insulin secretion under aerobic as well as anaerobic conditions. It is probable that adenosine triphosphate-sensitive potassium channels in beta-islet cells are involved in the different effects of sevoflurane anesthesia and propofol anesthesia on insulin secretion. Changes in both insulin secretion and insulin sensitivity during ischemia/reperfusion under propofol anesthesia are markedly different from those under sevoflurane anesthesia. During ischemia/reperfusion under propofol anesthesia, changes in insulin sensitivity seemed to be correlated with changes in plasma tumor necrosis factor-alpha levels.

与七氟烷麻醉相比，丙泊酚麻醉在有氧和无氧条件下均能增强胰岛素分泌。胰岛β细胞三磷酸腺苷敏感性钾通道可能参与了七氟醚麻醉和丙泊酚麻醉对胰岛素分泌的不同影响。异丙酚麻醉下缺血/再灌注期间胰岛素分泌和胰岛素敏感性的变化与七氟醚麻醉下明显不同。在丙泊酚麻醉下的缺血/再灌注期间，胰岛素敏感性的变化似乎与血浆肿瘤坏死因子-α水平的变化相关。

项目成果

The involvement of adenosine triphosphate-sensitive potassium channels in the different effects of sevoflurane and propofol on glucose metabolism in fed rats

三磷酸腺苷敏感钾通道参与七氟醚和丙泊酚对喂养大鼠葡萄糖代谢的不同影响

• DOI: 10.1213/ane.0b013e3182373552
• 发表时间: 2012
• 期刊: Anesthesia & Analgesia
• 影响因子: 5.7
• 作者: Takayuki Kitamura;Kanako Sato;Gaku Kawamura;Yoshitsugu Yamada
• 通讯作者: Yoshitsugu Yamada

麻酔管理と長期予後:周術期血糖コントロール

麻醉管理和长期预后：围手术期血糖控制

• 发表时间: 2011
• 作者: Takayuki Kitamura;Kanako Sato;Gaku Kawamura;Yoshitsugu Yamada;Takayuki Kitamura;北村享之
• 通讯作者: 北村享之