Effects of vecuronium bromide on central respiratory control and its passage through blood brain barrier in the in vivo rabbits

维库溴铵对家兔中枢呼吸控制及其通过血脑屏障的影响

• 批准号: 21791479
• 负责人: SAKURABA Shigeki
• 金额: $ 1.83万
• 依托单位: Kanagawa Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791479/
• 关键词: 筋弛緩薬; 呼吸中枢; 呼吸抑制; 非脱分極性筋弛緩薬; 中枢性呼吸調節機構; 血液脳関門; ベクロニウム; 横隔神経; アセチルコリン

Muscle relaxants used during operation are thought to cause postoperative respiratory depression due to their effects on respiratory muscles. However, in the animal experiment using newborn rats isolated-medulla, muscle relaxants also suppress central respiratory control. Therefore, in this experiment, effects of muscle relaxants injected peripheral vein on central respiratory control were analysed using the in vivo rabbits. Finally, it was found that high dose muscle relaxants suppressed respiratory control also in the in vivo rabbits

手术期间使用的肌肉松弛剂由于对呼吸肌的影响而被认为会导致术后呼吸抑制。然而，在使用新生大鼠离体髓质的动物实验中，肌肉松弛剂也会抑制中枢呼吸控制。因此，在本实验中，利用家兔在体分析了外周静脉注射肌松剂对中枢呼吸控制的影响。最后，发现高剂量的肌松剂也抑制了体内兔子的呼吸控制

项目成果

Donepezil reverses buprenorphine-induced central respiratory depression in anesthetized rabbits.

多奈哌齐可逆转麻醉兔子中丁丙诺啡引起的中枢呼吸抑制。

• 发表时间: 2009
• 期刊: Biological Research 42
• 作者: Sakuraba S;Tsujita M;Arisaka H;Takeda J;Yoshida K;Kuwana S
• 通讯作者: Kuwana S

Laudanosine has no effects on respiratory activity but inducesnon-respiratory excitement activity in isolated brainstem-spinal cord preoaration of neonatal rats.

劳丹诺辛对新生大鼠离体脑干-脊髓前旋的呼吸活动没有影响，但会诱导非呼吸兴奋活动。

• 发表时间: 2010
• 期刊: Advances in experimental medicine and biology 669
• 作者: Sakuraba S;et al.
• 通讯作者: et al.