Effects of vecuronium bromide on central respiratory control and its passage through blood brain barrier in the in vivo rabbits

由于手术期间使用的肌肉松弛剂对呼吸肌的影响，被认为会导致术后呼吸抑制。然而，在使用新生大鼠离体延髓的动物实验中，肌松药也抑制中枢呼吸控制。因此，本实验用在体家兔分析外周静脉注射肌松药对中枢呼吸控制的影响。最后，发现高剂量的肌松剂也抑制在体家兔的呼吸控制

Muscle relaxants used during operation are thought to cause postoperative respiratory depression due to their effects on respiratory muscles. However, in the animal experiment using newborn rats isolated-medulla, muscle relaxants also suppress central respiratory control. Therefore, in this experiment, effects of muscle relaxants injected peripheral vein on central respiratory control were analysed using the in vivo rabbits. Finally, it was found that high dose muscle relaxants suppressed respiratory control also in the in vivo rabbits