Development and analysis of a mouse model of preeclampsia using transient in vivo gene transfer system

近年来，“两步学说”作为子痫前期的病理状况受到广泛关注，具体而言，其根源被认为是妊娠早期绒毛膜侵入子宫不足导致胎盘灌注减少，而胎盘缺氧状态下某些血管生成因子抑制剂过度表达导致母体全身内皮功能障碍。本研究通过在着床窗口期将调节绒毛膜侵袭蜕膜的相关因子TIMP-3导入子宫腔，成功培育出子痫前期小鼠。

Recently, "Two Step Theory" has received a lot of attention as pathological condition of preeclampsia, concretely speaking, reduced placental perfusion due to insufficient chorionic invasion to the uterus at early pregnancy is postulated as the root cause and maternal systemic endothelial dysfunction is induced by some over-expressed inhibitor of angiogenesis factor due to hypoxic status at placenta. In this research, we transferred TIMP-3 which is known as related factor of regulation of chorionic invasion to the decidua into the uterine cavity during implantation window, thus we successfully developed a mouse of preeclampsia.