Effect of diet-induced obesity and its immuno-defect on sublingual immunotherapy.
Effect of diet-induced obesity and its immuno-defect on sublingual immunotherapy.
批准号:
21791781
负责人:
NAGAI Yasuhiro
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
Evidence from population studies shows that obesity clearly exacerbates a health risk. In this study we investigated the effects of diet-induced obesity on nickel allergy and anaphylactic shock and obtained the results below ; 1. Diet-induced obesity significantly reduced nickel allergy reaction. 2. Sublingual immunotherapy significantly reduces nickel allergy in normal mice, but there is no difference in obesity mice. OVA-induced anaphylactic shock did not occur in obesity mice.
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Histamine Reduces Susceptibility to NK Cells via Down-Regulation of NKG2D Ligand Expression on Human Monocytic Leukemia THP-1 Cells.
组胺通过下调人单核细胞白血病 THP-1 细胞的 NKG2D 配体表达来降低 NK 细胞的易感性。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Nagai Y., Tanaka Y., Kuroishi T., Sato R., Endo Y., Sugawara S.]
通讯作者:
Sugawara S.
Pro-IL-1β accumulation in macrophages by alendronate and its prevention by clodronate.
阿仑膦酸钠在巨噬细胞中积聚 IL-1β 前体以及氯膦酸钠对其的预防作用。
DOI:
--
发表时间:
2010
期刊:
Toxicology Letters
影响因子:
3.5
作者:
[Yosuke Shikama, Yasuhiro Nagai , Satoru Okada, Takefumi Oizum i, Hidetoshi Shimauchi, Shunji Sugawara, Yasuo Endo.]
通讯作者:
Yasuo Endo.
Histamine Reduces Susceptibility to NK Cells via Down-Regulation of NKG2D Ligand Expression on Human Monocytic Leukemia THP-1 Cells
组胺通过下调人单核细胞白血病 THP-1 细胞的 NKG2D 配体表达来降低 NK 细胞的易感性
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Nagai Y., Tanaka Y., Kuroishi T., Sato R., Endo Y., Sugawara S]
通讯作者:
Sugawara S
Analysis of antigen incorporating and processing cells in sublingal immunotherapy
舌下免疫治疗中抗原掺入和加工细胞的分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Shiraishi D., Nagai Y., Tanaka Y., Endo Y., Shimauchi H., Sugawara S]
通讯作者:
Sugawara S
Induction of Treg from PBMC by interacting with immunosuppressive B7-H3 molecule on oral mesenchymal stem cells from human gingival fibroblasts.
通过与来自人牙龈成纤维细胞的口腔间充质干细胞上的免疫抑制 B7-H3 分子相互作用,从 PBMC 中诱导 Treg。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Nagai Y., Shiraishi D., Ohki A., Tanaka Y., Aso H., Sugawara S.]
通讯作者:
Sugawara S.
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