The relationship between functional regulation of TRPV4 in oral epithelium and food preference

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I hypothesized that oral epithelial cells have perception of multi-stimuli in the oral environment. So I investigated the expression of TRPV4 channels, which were known as sensors for warm temperature, mechanical and chemical stimuli, in rat. T identified TRPV4 expression at mRNA and protein level. To investigate it's functional characters, I took advantage of electrophysiological and Ca2+imaging methods. Using TRPV4 activators and inhibitors, I observed TRPV4 induced currents and Ca2+ mobility.