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Nobel bone regenerative medicine promoted by regulation of human MSC by Wnt/sFRP family

Nobel bone regenerative medicine promoted by regulation of human MSC by Wnt/sFRP family
Wnt/sFRP家族调控人类MSC促进诺贝尔骨再生医学
批准号:
21791985
负责人:
KATAGIRI Wataru
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
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英文摘要
Recently it has been revealed that Wnt signaling pathway regulates the osteoblastic differentiation of human mesenchymal stem cells (hMSCs). We used sFRP-3, the antagonist of Wnt, to regulate this signaling and investigated the effect on osteoblastic differentiation of hMSCs in vitro and in vivo. It was revealed that the addition of sFRP-3 showed early differentiation and mineralization of hMSCs, and also showed early bone regeneration in animal model. These findings indicated the possibility of novel bone regenerative medicine using sFRP-3.
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DOI: 10.3892/ijo_00000761
发表时间: 2010-11-01
期刊: INTERNATIONAL JOURNAL OF ONCOLOGY
影响因子: 5.2
作者: [Iwai, Soichi, Yonekawa, Atsuko, Yura, Yoshiaki]
通讯作者: Yura, Yoshiaki
乳歯および永久歯歯髄細胞の遺伝子発現プロファイルの比較検討
乳牙和恒牙牙髓细胞基因表达谱的比较研究
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [前薗葉月, 野杁由一郎, 朝日陽子, 山口幹代, 山本れいこ, 薮根敏晃, 上田未央, 恵比須繁之, 中村さやか]
通讯作者: 中村さやか
Regulation of the Wnt signaling pathways during cell culture of human mesenchymal stem cells for efficient bone regeneration
人间充质干细胞培养过程中 Wnt 信号通路的调节以实现有效的骨再生
DOI: --
发表时间: 2010
期刊: Oral Science International (In press)
影响因子: --
作者: [Matsubara M, Yamachika E, Tsujigiwa H, Mizukawa N, Ueno T, Murakami J, Ishida N, Kaneda Y, Shirasu N, Takagi S., Katagiri W]
通讯作者: Katagiri W
ヒト乳歯歯髄由来幹細胞の細胞特性の検討Wnt/β-カテニン経路の関連
人乳牙牙髓干细胞的细胞特性检测与Wnt/β-catenin通路的关系
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Kita K, Murakami J, et al, 片桐渉]
通讯作者: 片桐渉
10
    Novel bone regenerative medicine with secretome from stem cells cultivated under the regulation of Wnt signaling pathway
    • 批准号:
      23592883
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.33万
    • 财政年份:
      2011
    • 负责人:
      KATAGIRI Wataru
    • 依托单位:
    Effects of Wnt signaling on the regenerative medicine of bone using stem cells
    • 批准号:
      19791504
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.09万
    • 财政年份:
      2007
    • 负责人:
      KATAGIRI Wataru
    • 依托单位:
    海外基金