Nobel bone regenerative medicine promoted by regulation of human MSC by Wnt/sFRP family
Nobel bone regenerative medicine promoted by regulation of human MSC by Wnt/sFRP family
批准号:
21791985
负责人:
KATAGIRI Wataru
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
Recently it has been revealed that Wnt signaling pathway regulates the osteoblastic differentiation of human mesenchymal stem cells (hMSCs). We used sFRP-3, the antagonist of Wnt, to regulate this signaling and investigated the effect on osteoblastic differentiation of hMSCs in vitro and in vivo. It was revealed that the addition of sFRP-3 showed early differentiation and mineralization of hMSCs, and also showed early bone regeneration in animal model. These findings indicated the possibility of novel bone regenerative medicine using sFRP-3.
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DOI:
10.3892/ijo_00000761
发表时间:
2010-11-01
期刊:
INTERNATIONAL JOURNAL OF ONCOLOGY
影响因子:
5.2
作者:
[Iwai, Soichi, Yonekawa, Atsuko, Yura, Yoshiaki]
通讯作者:
Yura, Yoshiaki
乳歯および永久歯歯髄細胞の遺伝子発現プロファイルの比較検討
乳牙和恒牙牙髓细胞基因表达谱的比较研究
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[前薗葉月, 野杁由一郎, 朝日陽子, 山口幹代, 山本れいこ, 薮根敏晃, 上田未央, 恵比須繁之, 中村さやか]
通讯作者:
中村さやか
Regulation of the Wnt signaling pathways during cell culture of human mesenchymal stem cells for efficient bone regeneration
人间充质干细胞培养过程中 Wnt 信号通路的调节以实现有效的骨再生
DOI:
--
发表时间:
2010
期刊:
Oral Science International (In press)
影响因子:
--
作者:
[Matsubara M, Yamachika E, Tsujigiwa H, Mizukawa N, Ueno T, Murakami J, Ishida N, Kaneda Y, Shirasu N, Takagi S., Katagiri W]
通讯作者:
Katagiri W
ヒト乳歯歯髄由来幹細胞の細胞特性の検討Wnt/β-カテニン経路の関連
人乳牙牙髓干细胞的细胞特性检测与Wnt/β-catenin通路的关系
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Kita K, Murakami J, et al, 片桐渉]
通讯作者:
片桐渉
DOI:
10.1016/j.joen.2009.07.024
发表时间:
2009-11-01
期刊:
JOURNAL OF ENDODONTICS
影响因子:
4.2
作者:
[Nakamura, Sayaka, Yamada, Yoichi, Ueda, Minoru]
通讯作者:
Ueda, Minoru
共 10 条
Novel bone regenerative medicine with secretome from stem cells cultivated under the regulation of Wnt signaling pathway
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批准号:23592883
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2011
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负责人:KATAGIRI Wataru
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依托单位:
Effects of Wnt signaling on the regenerative medicine of bone using stem cells
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批准号:19791504
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.09万
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财政年份:2007
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负责人:KATAGIRI Wataru
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依托单位:
海外基金