The study of the BNCT effect using the transferrin conjugate boron carriers on head and neck cancer

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We conducted a study using Liposome to examine the augmentation of the BNCT effect on oral squamous cell carcinoma. When it modified BSH in TF-PEG-liposome, it was confirmed immunohistochemically that the BSH transportation in cells was accomplished surely. It was actually confirmed that TF-PEG-liposome significantly showed a tumor killing effect as compared with BSH when we conducted neutron to cells. The results suggested that TF-PEG-liposome was useful for making BNCT effect increase.