Functional analysis of the cell cycle factors in the alveolar bone remodeling by the orthodontic force

细胞周期因子在正畸力重塑牙槽骨中的功能分析

• 批准号: 21792060
• 负责人: OHKUBO Kazumi
• 金额: $ 2.66万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21792060/
• 关键词: 歯科矯正; セルサイクル

It has been reported that cell cycle factors play important roles in both bone generation and bone resorption. The aim of this study was (1) to investigate the change of expression patterns of cell cycle factors in osteoblasts and osteoclasts in alveolar bone, where orthodontic force was applied and (2) to develop a new orthodontic treatment method by regulating cell cycle factors. First, an experimental model of tooth movement by orthodontic force was established. Second, I tried to investigate change of gene expression patterns of cell cycle factors in osteoblasts stimulated by orthodontic force. For this purpose, DNA micro array was performed to analyze cell cycle factors of which expression changed when osteoblast differentiation was promoted. Consequently, the expression levels of some transcription factors changed, whose role in osteogenesis had not been reported before. In addition, it was revealed that expressions of cyclin B1, cyclin E1 and p21 increased, and that of p57 decreased.

据报道，细胞周期因子在骨产生和骨吸收中都起着重要作用。这项研究的目的是（1）研究成骨细胞和破骨细胞中细胞周期因子的表达模式的变化，在肺泡骨中使用正畸力，（2）通过调节细胞周期因子来开发一种新的正畸治疗方法。首先，建立了正畸力的牙齿运动实验模型。其次，我试图研究正畸力刺激的成骨细胞中细胞周期因子的基因表达模式的变化。为此，进行了DNA微阵列以分析促进成骨细胞分化时表达改变的细胞周期因子。因此，某些转录因子的表达水平发生了变化，其在成骨中的作用尚未报道。此外，还发现细胞周期蛋白B1，细胞周期蛋白E1和p21的表达增加，p57的表达减少。

项目成果

Treatment of ankylosed maxillary central incisors by single-tooth dento-osseous osteotomy and alveolar bone distraction.

单牙牙骨截骨术和牙槽骨牵引治疗上颌中切牙强直。

• 发表时间: 2010
• 期刊: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. (Epub ahead of print)
• 作者: Kazumi Okubo;Takafumi Susami;Yoshiyuki Mori;Kouhei Nagahama;Naoko Takahashi;Hideto Saijo;Tsuyoshi Takato.
• 通讯作者: Tsuyoshi Takato.

Occlusion after orthodontic treatment in patients with unilateral alveolar cleft.

单侧牙槽裂患者正畸治疗后的咬合情况。

• 发表时间: 2009
• 作者: Kazumi OHKUBO;Takafumi SUSAMI;Kouhei NAGAHAMA;Natsuko UCHINO;Naoko ICHIKAWA;Masako MATSUZAKI;Yoshiyuki MORI;Tsuyoshi TAKATO.
• 通讯作者: Tsuyoshi TAKATO.

歯ならびの異常、不正咬合

牙齿排列异常、咬合不正

• 发表时间: 2010
• 期刊: 小児内科Jpn J Pediatr Med
• 作者: 大久保和美;ほか
• 通讯作者: ほか

Orthognatic Surgery in the Management of Occlusion for Patients with Cleft Lip and Palate.

正畸手术治疗唇裂和腭裂患者的咬合。

• 发表时间: 2009
• 作者: Takafumi SUSAMI;Yoshiyuki MORI;Kazumi OHKUBO;Madoka SUGIYAMA;Kouhei NAGAHAMA;Naoko ICHIKAWA;Natsuko UCHINO;Tsuyoshi TAKATO.
• 通讯作者: Tsuyoshi TAKATO.

歯ならびの異常

牙齿排列异常

• 发表时间: 2010
• 期刊: 不正咬合小児内科Jpn J Pediatr Med(6)特集;小児科医が知っておきたい境界領域疾患 Vol.42
• 作者: 大久保和美;須佐美隆史;高戸毅
• 通讯作者: 高戸毅