Functional analysis of the cell cycle factors in the alveolar bone remodeling by the orthodontic force

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It has been reported that cell cycle factors play important roles in both bone generation and bone resorption. The aim of this study was (1) to investigate the change of expression patterns of cell cycle factors in osteoblasts and osteoclasts in alveolar bone, where orthodontic force was applied and (2) to develop a new orthodontic treatment method by regulating cell cycle factors. First, an experimental model of tooth movement by orthodontic force was established. Second, I tried to investigate change of gene expression patterns of cell cycle factors in osteoblasts stimulated by orthodontic force. For this purpose, DNA micro array was performed to analyze cell cycle factors of which expression changed when osteoblast differentiation was promoted. Consequently, the expression levels of some transcription factors changed, whose role in osteogenesis had not been reported before. In addition, it was revealed that expressions of cyclin B1, cyclin E1 and p21 increased, and that of p57 decreased.