Elucidation of mechanisms for protective effects of NO-generating agents against radiation

阐明 NO 生成剂的辐射保护作用机制

• 批准号: 21651019
• 负责人: MATSUMOTO Hideki
• 金额: $ 2.26万
• 依托单位: University of Fukui
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21651019/
• 关键词: 防護; 一酸化窒素; 放射線防護剤; 狭心症治療薬; X線; 中性子線; 造血系細胞; 免疫系細胞; 放射線障害; 放射線防護; ヒト正常線維芽細胞; 正常マウス(jcl:ICR)

Among the drugs for angina pectoris and hyperpiesia, sodium nitroprusside, isosorbide dinitrate, nitroglycerin, nicorandil, nipradilol were selected and examined for the presence of protective activities against X-rays-induced injury and toxicities using normal human fibroblasts, AG1522cells. All drugs possessed protective activities against radiation and indicated non-toxicities up to 3μM.Furthermore, 5drugs were examined for the presence of protective activities against X-rays, mixed radiation(γ-rays and neutron) or neutron-induced injury and toxicities using normal mice(jcl : ICR, 8weeks old, male). All drugs were non-toxicities. However, Sodium nitroprusside only possessed protective activities against the injury induced by X-rays and it is due to promoting of restoration of hematopoietic and immune functions. Sodium nitroprusside was effective in the injury induced by mixed radiation, but not by neutrons alone.

在用于心绞痛和过度虔诚的药物中，选择并检查了使用正常的人类成纤维细胞AG15222222222222222222222222.所有药物均具有受保护活性的抗辐射活性，并指出了最高3μm的无毒性。FURTHERMORE，检查了5家药物是否存在针对X射线，混合辐射（γ射线和中子）或中子诱导的损伤和毒性的受保护活性，使用正常小鼠（JCL：ICR：ICR，8周，男性，男性，男性）。所有药物都是无毒的。然而，氮钠仅具有X射线诱发的损伤的受保护活性，这是由于促进造血和免疫功能的恢复。亚硝普钠在混合辐射引起的损伤中有效，但仅由中​​子而不是中子。

项目成果

Nitric Oxide is a Key Molecule Serving as a Bridge between Radiation-Induced Bystander and Adaptive Responses

• DOI: 10.2174/1874467211104020126
• 发表时间: 2011-05
• 期刊: Current Molecular Pharmacology
• 影响因子: 2.7
• 作者: H. Matsumoto;M. Tomita;Kensuke Otsuka;M. Hatashita;N. Hamada

放射線障害防護剤

辐射防护剂

• 发表时间: 2010

A new paradigm in radioadaptive response developing from charged heavy particle microbeam research.

带电重粒子微束研究开发的放射适应性响应的新范例。

• 发表时间: 2010
• 作者: Matsumoto;H.;Tbmita;M.;Otsuka;K.;Hatashita;M.
• 通讯作者: M.

粒子線誘発バイスタンダー応答による小腸および精巣でのアポトーシス

粒子束诱导的旁观者反应导致小肠和睾丸细胞凋亡

• 发表时间: 2010
• 作者: Matsumoto;H.;Tomita;M.;Otsuka;K.;Maeda;M.;Hatashita;M.;松本英樹;松本英樹;松本英樹;松本英樹,大塚健介,冨田雅典,畑下昌範
• 通讯作者: 松本英樹,大塚健介,冨田雅典,畑下昌範

A redox status of tumor microenvironment in cancer therapy.

癌症治疗中肿瘤微环境的氧化还原状态。

• 发表时间: 2010
• 作者: Matsumoto;H.
• 通讯作者: H.