Elucidation of mechanisms for protective effects of NO-generating agents against radiation

阐明 NO 生成剂的辐射保护作用机制

• 批准号: 21651019
• 负责人: MATSUMOTO Hideki
• 金额: $ 2.26万
• 依托单位: University of Fukui
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21651019/
• 关键词: 防護; 一酸化窒素; 放射線防護剤; 狭心症治療薬; X線; 中性子線; 造血系細胞; 免疫系細胞; 放射線障害; 放射線防護; ヒト正常線維芽細胞; 正常マウス(jcl:ICR)

Among the drugs for angina pectoris and hyperpiesia, sodium nitroprusside, isosorbide dinitrate, nitroglycerin, nicorandil, nipradilol were selected and examined for the presence of protective activities against X-rays-induced injury and toxicities using normal human fibroblasts, AG1522cells. All drugs possessed protective activities against radiation and indicated non-toxicities up to 3μM.Furthermore, 5drugs were examined for the presence of protective activities against X-rays, mixed radiation(γ-rays and neutron) or neutron-induced injury and toxicities using normal mice(jcl : ICR, 8weeks old, male). All drugs were non-toxicities. However, Sodium nitroprusside only possessed protective activities against the injury induced by X-rays and it is due to promoting of restoration of hematopoietic and immune functions. Sodium nitroprusside was effective in the injury induced by mixed radiation, but not by neutrons alone.

在治疗心绞痛和高血压的药物中，选择硝普钠、硝酸异山梨酯、硝酸甘油、尼可地尔、尼普拉地洛，用正常人成纤维细胞AG1522细胞检测其对X射线损伤和毒性的保护作用。所有药物均具有辐射防护作用，毒性最高可达3μM。此外，用正常小鼠(γ：ICR，8周龄，雄性)检测了5种药物对X射线、混合辐射(X射线和中子)或中子损伤的保护作用。所有药物都是无毒的。而硝普钠仅对X射线损伤有保护作用，其机制可能与促进造血和免疫功能的恢复有关。硝普钠对混合辐射损伤有效，但对单纯中子损伤无效。

项目成果

Nitric Oxide is a Key Molecule Serving as a Bridge between Radiation-Induced Bystander and Adaptive Responses

• DOI: 10.2174/1874467211104020126
• 发表时间: 2011-05
• 期刊: Current Molecular Pharmacology
• 影响因子: 2.7
• 作者: H. Matsumoto;M. Tomita;Kensuke Otsuka;M. Hatashita;N. Hamada

放射線障害防護剤

辐射防护剂

• 发表时间: 2010

A new paradigm in radioadaptive response developing from charged heavy particle microbeam research.

带电重粒子微束研究开发的放射适应性响应的新范例。

• 发表时间: 2010
• 作者: Matsumoto;H.;Tbmita;M.;Otsuka;K.;Hatashita;M.
• 通讯作者: M.

低線量被ばくを考える

考虑低剂量暴露

• 发表时间: 2012
• 作者: Matsumoto;H.;松本英樹
• 通讯作者: 松本英樹

陽子線がん治療における低線量被ばくによる正常組織反応の機構解明

阐明质子束癌症治疗中低剂量暴露引起的正常组织反应机制

• 发表时间: 2011
• 作者: Matsumoto;H.;松本英樹;松本英樹;松本英樹;松本英樹;前田宗利,松本英樹,宇佐美徳子,小林克己,冨田雅典;大塚健介,浜田信行,馬替純二,松本英樹,塚本徹哉,星裕子,野村崇冶,冨田雅典,前田宗利,吉田和生,丹羽太貴,岩崎利泰;松本英樹,渡邊正巳,田内広,立花章,鈴木啓司,宇佐美徳子,松本義久;松本英樹,冨田雅典,大塚健介,前田宗利,畑下昌範;松本英樹,畑下昌範
• 通讯作者: 松本英樹,畑下昌範