Identificationand the analysis of the genes involvedin photoreceptor morphogenesis and maintenance in Drosophila

我们筛选了与视紫红质转运有关的新基因，并发现两个基因是糖基磷脂酰肌醇(GPI)合成/附着过程的缺陷导致TGN中红紫质顶端转运的丧失(Development，2013)。在研究Arrstin介导的信号转导的过程中，我们发现Arr2在果蝇光感受器中的转位是由扩散驱动的，但受到光转导和钙内流的深刻促进(Neuron 2010，J.Neursci)。2012年)

We screened to identify new genes involved in Rhodopsin transport andfound two that the deficiency of glycosylphosphatidylinositol (GPI) synthesis/attachment processes causes the loss of the apical transport of Rhodopsinfrom the TGN (Development, 2013). In the process of studying Arrstin mediated signaling, we found that Arr2 translocation in Drosophilaphotoreceptors is driven by diffusion, but profoundly accelerated by phototransduction and Ca2+influx (Neuron 2010, J. Neursci. 2012)