Mechanism of small RNA generation controlling chromosome function

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In addition to a cellular defense mechanism against the foreign genetic elements, the RNA interference machinery is involved in the control of RNA molecules derived from the internal genome. It contributes to the heterochromatin assembly of target RNA-generating loci in fission yeast. In this research, we revealed that RNA splicing pathway is partly involved in the targeting of RNA interference machinery to the cognate RNAs. We further showed the relationship between RNA interference machinery and spatiotemporal regulation of heterochromatin higher order structure within the nucleus.