Real-time visualization of transposon dynamics in the course of chromosome rearrangement

转座子除了通过转座对宿主细胞的转录回路产生干扰影响外，由于其沿染色体的重复和穿插性质，转座子可能具有产生各种总体染色体重排的能力。在本研究中，我们可视化了诱导染色体重排过程中的实时转座子动力学，并探讨了转座子对这一事件的直接贡献。

In addition to its disturbing influence on the transcriptional circuit in host cells by transposition, transposon potentially has an ability to generate various gross chromosomal rearrangements by virtue of its repetitive and interspersed nature along the chromosomes. In this study, we visualize the real-time transposon dynamics in the course of induced chromosome rearrangement, and investigate the direct contribution of transposons to the event. Our results suggest that the chromosome rearrangement may not be a consequence of an unintended failure of genome surveillance machinaries, but a consequence of actively liberating transposon and making use of its massive chromosome transfiguration ability.