The Development of Normothermic Perfusion Preservation and"Post-conditioning"Methods in Liver Transplantation

肝移植常温灌注保存及“后处理”方法的进展

• 批准号: 21689035
• 负责人: HATA Koichiro
• 金额: $ 11.65万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21689035/
• 关键词: 灌流保存; 肝移植; ADAMTS13; 臓器移植; 生体肝移植; 臓器保存

In this study, we developed a pressure controlled perfusion preservation system, and evaluated the "Post-conditioning" effects in perfusion preservation with Isolated Perfused Rat Liver. It is plausible that normothermic perfusion preservation may preserve/improve the liver function better than cold storage, which is the gold standard preservation method, with protecting hepatic sinusoids.

本研究建立了一种压力控制的离体大鼠肝脏灌注保存系统，并对“后处理”在离体大鼠肝脏灌注保存中的作用进行了评价。常温灌注保存在保护肝血窦的同时，可能比作为金标准保存方法的低温保存更好地保存/改善肝功能。

项目成果

Liver Transplantation for Congenital Biliary Dilatation: A Single-Center Experience

• DOI: 10.1159/000319373
• 发表时间: 2010-01-01
• 期刊: DIGESTIVE SURGERY
• 影响因子: 2.7
• 作者: Hori, Tomohide;Oike, Fumitaka;Uemoto, Shinji
• 通讯作者: Uemoto, Shinji

Posttransplant Bacteremia in Adult Living Donor Liver Transplant Recipients

• DOI: 10.1002/lt.22165
• 发表时间: 2010-12-01
• 期刊: LIVER TRANSPLANTATION
• 影响因子: 4.6
• 作者: Iida, Taku;Kaido, Toshimi;Uemoto, Shinji
• 通讯作者: Uemoto, Shinji

Thrombotic microangiopathy-likedisorder after living-donor livertrans plantation

活体肝移植后血栓性微血管病样疾病

• 发表时间: 2011
• 期刊: A single-center experiencein Japan. World J Gastroenterol. 17(14)
• 作者: Hori T;Kaido T;Hata K;et al(23人中7番目)
• 通讯作者: et al(23人中7番目)

Comprehensive and innovative techniques for liver transplantation in rats: A surgical guide

• DOI: 10.3748/wjg.v16.i25.3120
• 发表时间: 2010-07-07
• 期刊: WORLD JOURNAL OF GASTROENTEROLOGY
• 影响因子: 4.3
• 作者: Hori, Tomohide;Nguyen, Justin H.;Uemoto, Shinji
• 通讯作者: Uemoto, Shinji

ADAMTS13, von Willebrand factorcleaving protease, activity and livergraft preservation; -how to reduce therisk for thrombotic microangiopathy-

ADAMTS13，冯维勒布兰德因子裂解蛋白酶，活性和肝移植物保存；

• 发表时间: 2011
• 作者: Hirokazu Tanaka;Koichiro Hata
• 通讯作者: Koichiro Hata