Generation of Diabetic model mouse using improved toxin receptor

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Previously we generated the diabetic model mouse by using TRECK method. This model mouse can be determined when to develop diabetes by the administration of Diphtheria toxin (DT). We can also control the level of the symptom. However, the transgenic mouse displayed abnormality in glucose tolerance and islet structure even without DT treatment. In this study, to solve these problems found in the model mouse, we generated improved TRECK diabetic model mice using a modified DT receptor. The new diabetic model mice showed normal architecture of pancreatic islets before DT treatment and they developed hyperglycemia after DT administration.