Developments of phosphorescence probes for oxygen concentration measurements of ex vivo and in vivo environment

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The phosphorescence probes for elucidation of oxygen dynamics in lipid bilayers, cells, and tissues were developed. The synthesized iridium complexes showed high intensity phosphorescence in near-infrared region, and dissolved in water. The photochemical and photophysical properties of these complexes in solutions, lipid membranes and cells were revealed. Based on these data, the optical imaging of tumor in nude mice using these complexes was carried out, and iridium complexes have a vast potential for imaging hypoxic lesions.