The study of clinically relevant radioresistant cells for the development of more effective tumor radiotherapy
The study of clinically relevant radioresistant cells for the development of more effective tumor radiotherapy
批准号:
21710055
负责人:
KUWAHARA Yoshikazu
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
x射线诱导的自噬细胞死亡在辐射抗性细胞中受到抑制。雷帕霉素是一种诱导自噬的药物,可使耐辐射细胞致敏。诱导自噬是克服放射耐药肿瘤的有效途径。
英文摘要
X-ray induced autophagic cell death is suppressed in radioresistant cells. Administration of rapamycin, an induced of autophagy, sensitized radioresistant cells. Induction of autophagy would be the effective modality to overcome radioresistant tumor.
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Histological type of Thorotrast‐induced liver tumors associated with the translocation of deposited radionuclides
与沉积的放射性核素易位相关的Thorotrast诱发的肝脏肿瘤的组织学类型
DOI:
10.1111/j.1349-7006.2009.01401.x
发表时间:
2010
期刊:
Cancer Science
影响因子:
5.7
作者:
[Yoichiro Yamamoto, J. Chikawa, Yoshinobu Uegaki, N. Usuda, Y. Kuwahara, M. Fukumoto]
通讯作者:
M. Fukumoto
DOI:
10.1269/jrr.09107
发表时间:
2010-03-01
期刊:
JOURNAL OF RADIATION RESEARCH
影响因子:
2
作者:
[Hidaka, Masayuki, Oda, Shoji, Mitani, Hiroshi]
通讯作者:
Mitani, Hiroshi
DOI:
10.1111/j.1349-7006.2009.01082.x
发表时间:
2009-04-01
期刊:
CANCER SCIENCE
影响因子:
5.7
作者:
[Kuwahara, Yoshikazu, Li, Li, Fukumoto, Manabu]
通讯作者:
Fukumoto, Manabu
DOI:
10.1269/jrr.09094
发表时间:
2010-05-01
期刊:
JOURNAL OF RADIATION RESEARCH
影响因子:
2
作者:
[Kuwahara, Yoshikazu, Mori, Miyuki, Fukumoto, Manabu]
通讯作者:
Fukumoto, Manabu
Long incubation period from the induction of cancer by Thorotrast is attributed to the uneven irradiation of hepatocytes at the microscopic level
Thorotrast诱发癌症的潜伏期长是由于微观水平上肝细胞照射不均匀所致
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Y YAMAMOTO, N USUDA, T TAKATSUJI, Y KUWAHARA, M FUKUMOTO]
通讯作者:
M FUKUMOTO
共 29 条
Involvement of mitochondria in cancer cell radioresistance
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批准号:16K00538
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2016
-
负责人:KUWAHARA Yoshikazu
-
依托单位:
X-ray induced autophagy in radioresistant cells
-
批准号:23710066
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.91万
-
财政年份:2011
-
负责人:KUWAHARA Yoshikazu
-
依托单位:
Screening of the candidate gene involved in clinically relevant radioresistance
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批准号:19710049
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.32万
-
财政年份:2007
-
负责人:KUWAHARA Yoshikazu
-
依托单位:
海外基金