Roles of maturation of presynaptic functions in the postnatal refinement of neuronal circuits.

用膜片钳记录技术观察了小鼠下橄榄(IO)神经元生后电生理特性的变化。从出生后7天(P7)至15天，动作电位阈值升高，输入阻抗降低。这些发育变化与缝隙连接的形成是一致的。此外，亚阈值振荡也是在这一出生后时期开始的。这些结果表明，IO神经元在P7至P15之间获得成人型细胞膜特性。

Postnatal changes of electrophysiological properties of inferior olivery (IO) neurons are examined by the patch clamp recording using slices prepared from mouse medulla. The threshold of action potential was increasedand input resistance was decreased from postnatal day 7 (P7) to P15. These developmental changes proceeded coincident with the formation of the gap junction. Moreover, the subthreshold oscillation also started during this postnatal period. These results suggestthat IO neurons gain their adult type membrane properties from P7 to P15.