The role of carbohydrates including galactose and sialic acids in higher brain functions

为了阐明碳水化合物在高级脑功能中的作用，我们使用行为分析研究了糖原操纵小鼠。β4GalT-2 KO小鼠和C6 ST-1 Tg小鼠表现出对新刺激的超敏反应和注意力紊乱，并被认为是多巴胺系统受损。β4GalT-5 KO小鼠和β4GalT-6 KO小鼠表现出异常活动和注意力障碍，并提示髓鞘形成受损。这些结果表明，碳水化合物在高级脑功能中起着重要作用。

To elucidate the role of carbohydrates in higher brain functions, we investigated glycogene-manipulated mice using behavioral analysis. β4GalT-2 KO mice and C6ST-1 Tg mice showed hypersensitive to novel stimuli and disturbed attention, and were suggested to be impaired in the dopamine system. β4GalT-5 KO mice and β4GalT-6 KO mice showed abnormal activity and disturbed attention, and were suggested to be impaired in myelin formation. These results indicated that carbohydrates play an important role in higher brain functions.