Development of novel bioadhesive and joint materials having nano-scale fibrous structures

本论文对静电纺丝纤维素、壳聚糖、羟丙基纤维素无纺布进行化学改性，制备固定化海洋和淡水生物粘性肽结构域的生物粘附材料。 这些新型粘附材料的成功制备表明它们在固定化酶或组织工程材料中的应用。 本论文还利用水生昆虫的丝蛋白制备了静电纺无纺布，所得的纳米纤维结构具有良好的性能，可作为成骨细胞培养的支架材料等。

Chemical modification of electrospun cellulose, chitosan, hydroxypropyl cellulose non-woven fabrics were examined for development of biological adhesive materials, which immobilized sticky peptide domain inspired from marine and freshwater organisms. The successful preparations of those novel adhesive materials suggest their applications for immobilized enzymes, or, tissue engineering materials. A silk protein from aquatic insect was also tested for preparation of electrospun non-woven fabrics and resulting nano-fibrous structure is promising properties to be applied as scaffolds for osteoblast cultures and so on.