Development of novel bioadhesive and joint materials having nano-scale fibrous structures

研究了电纺纤维素、壳聚糖、羟丙基纤维素无纺布的化学改性，开发了固定化海洋和淡水生物粘肽结构域的生物粘接材料。这些新型黏附材料的成功制备为固定化酶或组织工程材料提供了应用前景。从水生昆虫中提取的丝蛋白也被测试用于制备静电纺无纺布，所得纳米纤维结构具有应用于成骨细胞培养等方面的良好性能。

Chemical modification of electrospun cellulose, chitosan, hydroxypropyl cellulose non-woven fabrics were examined for development of biological adhesive materials, which immobilized sticky peptide domain inspired from marine and freshwater organisms. The successful preparations of those novel adhesive materials suggest their applications for immobilized enzymes, or, tissue engineering materials. A silk protein from aquatic insect was also tested for preparation of electrospun non-woven fabrics and resulting nano-fibrous structure is promising properties to be applied as scaffolds for osteoblast cultures and so on.