Practical Use of Biodegradable Functional Materials Created from Water, Light, and natural Polymers.

1.水法合成光交联聚氨基酸及其在杂化纤维中的应用研究了聚l -赖氨酸（PLL）和聚l -鸟氨酸（PLO）两种阳离子多肽，将光反应性的香豆基氧乙酰基加入到PLL和PLO的侧链氨基中。将得到的含香豆素的阳离子多肽与阴离子多糖结冷胶在水中纺成PIC纤维。在光照作用下，含香豆素的PIC纤维的机械强度进一步提高。在水溶液界面上自组装制备生物聚合物杂化胶囊壳聚糖和结冷胶在水溶液中通过聚离子络合物（polyion complex， PIC）形成的静电多糖相互作用形成真正的球形胶囊。在结冷胶溶液中滴入壳聚糖溶液，得到外表面为结冷胶，内表面为壳聚糖的球形胶囊。用低分子量物质和高分子量蛋白质考察了微胶囊的释放特性。对于低分子量物质，其释放动力学受引力和斥力的影响。物质与胶囊内部成分之间的相互作用。被包被物质的分子量也会影响释放动力学。增强纤维材料的灵感来自于海洋贻贝的自发系统海洋贻贝自发系统的分子机制激发了在水介质中制造混合材料的新技术。在我们制造仿生杂交纤维、胶囊、水凝胶和粘合剂的一系列研究中，我们重点研究了伴随足丝形成而发生的醌偶联化学。设计并合成了新型多糖和聚氨基酸衍生物。它们有嫁接的肽侧chan作为酶介导的交联剂，允许杂交材料的机械增强。少

1.Synthesis of photo-crosslinkable poly(amino acids by watery process and its application for hybrid fibersTwo kinds of cationic polypeptides, poly(L-lysine) (PLL) and poly(L-ornithine) (PLO) were treated to incorporate the photoreactive coumaryloxyacetyl groups into the side chain amino groups of the PLL and PLO. The resulting coumarin-containing cationic polypeptides were spun into the PIC fibers with the anionic polysaccharide gellan in water. The mechanical strength of the coumarin-containing PIC fibers further increased upon light-irradiation.2.Preparation of Biopolymer Hybrid Capsules Formed by Self-Assembly at an Aqueous Solution InterfaceTrue spherical capsules are formed by electrostatic polysaccharide interaction between chitosan and gellan gum via polyion complex (PIC) formation in aqueous solutions. Dropwise addition of a chitosan solution into the gellan solution gave spherical capsules whose outside surface was gellan and whose inside was chitosan. The releasing propertie … More s of the capsules were examined using low molecular weight substances and high molecular weight proteins. For low molecular weight substances, the releasing kinetics were affected by the attractive and repulsive. interactions between the substances and the inside component of the capsule. The molecular weight of the encapsulated substances also affects the releasing kinetics.3.Reinforced Fiber Material Inspired from the Byssogenous System of the Marine MusselThe molecular mechanism involved in the byssogenous system of the marine mussels inspires the mew technology for creating a hybrid material in aqueous media. In a series of our studies to create the biomimetic hybrid fibers, capsules, hydrogels, and adhesives, we focused on the quinone-coupling chemistry, which occurs along with the byssus formation. The novel polysaccharide and poly(amino acid) derivatives were designed and synthesized. They have the grafted peptide side chan as the enzyme-mediated cross-linker, allowing the mechanical reinforcement of the hybrid materials. Less