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Practical Use of Biodegradable Functional Materials Created from Water, Light, and natural Polymers.

由水、光和天然聚合物制成的可生物降解功能材料的实际应用。

基本信息

批准号：
13556057
负责人：
OHKAWA Kousaku
金额：
$ 2.75万
依托单位：
Shinshu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

项目摘要

1.Synthesis of photo-crosslinkable poly(amino acids by watery process and its application for hybrid fibersTwo kinds of cationic polypeptides, poly(L-lysine) (PLL) and poly(L-ornithine) (PLO) were treated to incorporate the photoreactive coumaryloxyacetyl groups into the side chain amino groups of the PLL and PLO. The resulting coumarin-containing cationic polypeptides were spun into the PIC fibers with the anionic polysaccharide gellan in water. The mechanical strength of the coumarin-containing PIC fibers further increased upon light-irradiation.2.Preparation of Biopolymer Hybrid Capsules Formed by Self-Assembly at an Aqueous Solution InterfaceTrue spherical capsules are formed by electrostatic polysaccharide interaction between chitosan and gellan gum via polyion complex (PIC) formation in aqueous solutions. Dropwise addition of a chitosan solution into the gellan solution gave spherical capsules whose outside surface was gellan and whose inside was chitosan. The releasing propertie … More s of the capsules were examined using low molecular weight substances and high molecular weight proteins. For low molecular weight substances, the releasing kinetics were affected by the attractive and repulsive. interactions between the substances and the inside component of the capsule. The molecular weight of the encapsulated substances also affects the releasing kinetics.3.Reinforced Fiber Material Inspired from the Byssogenous System of the Marine MusselThe molecular mechanism involved in the byssogenous system of the marine mussels inspires the mew technology for creating a hybrid material in aqueous media. In a series of our studies to create the biomimetic hybrid fibers, capsules, hydrogels, and adhesives, we focused on the quinone-coupling chemistry, which occurs along with the byssus formation. The novel polysaccharide and poly(amino acid) derivatives were designed and synthesized. They have the grafted peptide side chan as the enzyme-mediated cross-linker, allowing the mechanical reinforcement of the hybrid materials. Less

1.光交联聚氨基酸的水相法合成及其在杂化纤维中的应用对两种阳离子多肽聚L-赖氨酸（PLL）和聚L-鸟氨酸（PLO）进行处理，使其侧链氨基上引入光反应性的香豆酰氧基乙酰基。将所得含香豆素的阳离子多肽与阴离子多糖结冷胶在水中纺成PIC纤维。含香豆素的PIC纤维的机械强度在光照射下进一步增加。2.在水溶液界面通过自组装形成的生物聚合物杂化胶囊的制备真正的球形胶囊是通过壳聚糖和结冷胶之间的静电多糖相互作用通过在水溶液中形成聚离子络合物（PIC）而形成的。将壳聚糖溶液滴加到结冷胶溶液中得到球形胶囊，其外表面是结冷胶，其内部是壳聚糖。释放特性 ...更多信息使用低分子量物质和高分子量蛋白质检查胶囊的S。对于低分子量物质，释放动力学受吸引力和排斥力的影响。物质与胶囊内部成分之间的相互作用。3.海洋贝类纤维素系统的增强纤维材料海洋贝类纤维素系统的分子机制激发了在水介质中制备杂化材料的新技术。在一系列的研究中，我们创造了仿生混合纤维，胶囊，水凝胶和粘合剂，我们专注于醌偶联化学，它发生沿着足丝的形成。设计并合成了新型多糖和聚氨基酸衍生物。它们具有作为酶介导的交联剂的接枝肽侧链，允许杂化材料的机械增强。少