Development of bone-compatible interface using bioresorbable calcium phosphate coating film

对在商业纯钛上形成的无定形磷酸钙膜进行了体内和体外评价。将涂有无定形磷酸钙的钛植入白色家兔的股骨和胫骨。无定形磷酸钙涂层显著改善了钛种植体的种植体稳定性系数（ISQ）和骨种植体接触。涂层膜在两周的植入期间被吸收;由于这种吸收而释放的钙和磷相关离子被认为在骨相容性的改善中起重要作用。此外，添加铌的无定形磷酸钙膜是一种有效的技术，以控制其在生物环境中的可吸收性。

In vivo and in vitro evaluations of an amorphous calcium phosphate film formed on commercially pure titanium were conducted. Titanium implants coated with amorphous calcium phosphate were given to the femur and tibia of white rabbits. The implant stability quotient (ISQ) and bone implant contact for titanium implants were statistically improved by the coating of amorphous calcium phosphate. The coating film was absorbed during an implantation period of two-weeks; the release of Ca and P-related ions due to this absorption was suggested to play an important role in the improvement of bone compatibility. Further, the addition of Nb to the amorphous calcium phosphate film was an effective technique to control its resorbability in biological environments.