Development of bone-compatible interface using bioresorbable calcium phosphate coating film

对在工业纯钛上形成的无定形磷酸钙薄膜进行了体内和体外评价。将无定形磷酸钙涂层的钛种植体植入大白兔的股骨和胫骨。无定形磷酸钙涂层显著提高了钛种植体的稳定性商数(ISQ)和种植体与骨的接触性。涂层在两周的植入过程中被吸收，这种吸收导致的钙磷相关离子的释放在改善骨的相容性中起着重要作用。此外，在无定形磷酸钙薄膜中添加Nb是控制其在生物环境中的吸收率的有效技术。

In vivo and in vitro evaluations of an amorphous calcium phosphate film formed on commercially pure titanium were conducted. Titanium implants coated with amorphous calcium phosphate were given to the femur and tibia of white rabbits. The implant stability quotient (ISQ) and bone implant contact for titanium implants were statistically improved by the coating of amorphous calcium phosphate. The coating film was absorbed during an implantation period of two-weeks; the release of Ca and P-related ions due to this absorption was suggested to play an important role in the improvement of bone compatibility. Further, the addition of Nb to the amorphous calcium phosphate film was an effective technique to control its resorbability in biological environments.