Molecular dissection of the organization and dynamics of lipid domains in biomembranes

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We established a method to visualize major components of lipid rafts, sphingomyelin and cholesterol, in sub-micron scale.New screening protocol using lipid imaging was employed to isolate a new inhibitor of sphingomyelin biosynthesis.The role of sphingomyelin to regulate the transbilayer movement of lipid second messengers such as ceramide and diacylglycerol was elucidated.The unusual stereoconfiguration of endosome-specific lipid was determined.