Therapeutic strategy for diabetic angiopathy using AGE aptamer

AGE适体治疗糖尿病血管病的策略

• 批准号: 22390111
• 负责人: YAMAGISHI Shoichi
• 金额: $ 11.15万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390111/
• 关键词: 糖尿病; AGE; AGEアプタマー; AGE-アプタマー; 血管障害; 腎症; 血管合併症

Continuous infusion of DNA aptamer raised against advanced glycation end products (AGE) not only blocked the development and progression of diabetic microangiopathy by reducing proteinuria and inflammatory reactions in the kidney and retina, but also inhibited balloon-injured neointima formation in diabetic rats. AGE-aptamer may be a novel therapeutic strategy for diabetic angiopathy

持续输注针对晚期糖基化终产物（AGE）的DNA适体不仅通过减少蛋白尿和肾脏及视网膜的炎症反应来阻断糖尿病微血管病变的发生和进展，而且还抑制糖尿病大鼠球囊损伤的新生内膜形成。AGE-aptamer可能成为糖尿病血管病变治疗的新策略

项目成果

AGEs-DNAアプタマーは糖尿病性腎症の糸球体硬化を改善する

AGEs-DNA适体改善糖尿病肾病的肾小球硬化

• 发表时间: 2011
• 作者: 甲斐田祐介;深水圭;上田誠二;山岸昌一;奥田誠也
• 通讯作者: 奥田誠也

DNA aptamer raised against AGEs blocks the progression of experimental diabetic nephropathy.

• DOI: 10.2337/db12-1608
• 发表时间: 2013-09
• 期刊: Diabetes
• 影响因子: 7.7
• 作者: Kaida Y;Fukami K;Matsui T;Higashimoto Y;Nishino Y;Obara N;Nakayama Y;Ando R;Toyonaga M;Ueda S;Takeuchi M;Inoue H;Okuda S;Yamagishi S
• 通讯作者: Yamagishi S