The analysis of molecular pathogenesis and mechanisms for antiphospholipid syndrome

抗磷脂综合征的分子发病机制及机制分析

• 批准号: 22390198
• 负责人: KOIKE Takao
• 金额: $ 11.98万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390198/
• 关键词: 抗リン脂質抗体症候群; β2GPI; プロテオミクス; 抗β2-GPI抗体; 酸化LDL; 自己抗体; 抗リン脂質抗体; 血栓症; 単球; 質量分析; プロテオーム

Oxidized LDL was detected as a major β2GPI binding plasma molecule by proteomics analysis. The presence of oxidized LDL upregulated aCL/β2GPI induced TF expression on monocytes, suggesting the involvement of oxidized LDL in the pathophysiology of thrombosis in patients with APS. LpPLA2, oxidized LDL related molecule, was higher expressed in plasma of patients with APS than those without. As performing SNP analysis for LpPLA2 related genes detected by GWAS, two risk alleles were more frequent in patients with APS compared to healthy controls, suggesting that gene anomaly in patients with APS was partially involved in high expression of oxidized LDL in patients with APS.

通过蛋白质组学分析检测到氧化LDL是β2GPI结合的主要血浆分子。氧化LDL的存在上调了aCL/β2GPI诱导的单核细胞TF表达，提示氧化LDL参与了APS患者血栓形成的病理生理过程。氧化型低密度脂蛋白相关分子LpPLA 2在APS患者血浆中的表达高于无APS者。对GWAS检测到的LpPLA 2相关基因进行SNP分析，发现APS患者中有两个危险等位基因的频率高于健康对照，提示APS患者的基因异常部分参与了APS患者氧化型LDL的高表达。

项目成果

Up-regulated expression of HLA-DRB5 transcripts and high frequency of the HLA-DRB5*01:05 allele in scleroderma patients with interstitial lung disease

• DOI: 10.1093/rheumatology/kes149
• 发表时间: 2012-10-01
• 期刊: RHEUMATOLOGY
• 影响因子: 5.5
• 作者: Odani, Toshio;Yasuda, Shinsuke;Koike, Takao
• 通讯作者: Koike, Takao

T cells from patients with systemic lupus erythematosus

来自系统性红斑狼疮患者的 T 细胞

• 发表时间: 2011
• 作者: Yasuda S;Kono M;Koike;et al.
• 通讯作者: et al.

The role of immunosuppressive therapy for pulmonary arterial hypertension complicated with connective tissue disease : long-term follow-up of 5 cases.

免疫抑制剂治疗肺动脉高压合并结缔组织病的作用：长期随访5例。

• 发表时间: 2010
• 作者: Kato M;Atsumi T;Koike T;et al.
• 通讯作者: et al.

Novel Lupus Susceptible Gene Polymorphisms in Patients with Sjogren's Syndrome in Japanese Population.

日本干燥综合征患者的新狼疮易感基因多态性。

• 发表时间: 2010
• 作者: Horita T;Atsumi T;Koike T;et al.
• 通讯作者: et al.

Predominant prevalence of stroke in Japanese patients with antiphospholipid syndrome

日本抗磷脂综合征患者中风的主要患病率

• 发表时间: 2011
• 作者: Fujieda Y;Atsumi T;AKoike T;et al.
• 通讯作者: et al.