Understanding of non-canonical Wnt signaling network in bone and cartilage formation
Understanding of non-canonical Wnt signaling network in bone and cartilage formation
批准号:
22390348
负责人:
NISHIMURA Riko
金额:
$12.23万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
To understand the role of non-canonical Wnt including Wnt5a, weinvestigated the phenotype of Wnt5a null mice. The Wnt5a null mice showed severe impairment of skeletal development, especially in cartilage formation. We have attempted to identify the target of Wnt5a, and found that homeobox gene would be involved in Wnt5a-regulated endochondral ossification.
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Regulation of bone and cartilage development by network between BMP signaling and transcription factors.
通过 BMP 信号和转录因子之间的网络调节骨和软骨发育。
DOI:
--
发表时间:
2012
期刊:
J Biochem
影响因子:
2.7
作者:
[Nishimura R, Hata K, Mastubara T, Wakabayashi M, Yoneda T]
通讯作者:
Yoneda T
骨芽細胞の分化制御機構
成骨细胞分化控制机制
DOI:
--
发表时间:
2011
期刊:
Clinical Calcium
影响因子:
--
作者:
[Hayakawa, T., Kato, K., Hayakawa, R., Hisamoto, N., Matsumoto, K., Takeda, K.and Ichijo, H., 西村理行]
通讯作者:
西村理行
転写因子 Arid5bは Sox9標的遺伝子プロモーター領域のヒストン脱メチル化を介して軟骨細胞分化を促進する
转录因子 Arid5b 通过 Sox9 靶基因启动子区域的组蛋白去甲基化促进软骨细胞分化
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[波多 賢二, 高島利加子, Whitson RH, 西村理行, 米田俊之]
通讯作者:
米田俊之
Regulation of bone development by Sox9 and Osterix
Sox9 和 Osterix 对骨骼发育的调节
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Sadatomi, D., Takeda, K., Nishimura R]
通讯作者:
Nishimura R
内軟骨性骨形成過程における転写因子の役割と機能制御
转录因子在软骨内骨形成过程中的作用和功能调控
DOI:
--
发表时间:
2012
期刊:
Clinical Calcium
影响因子:
--
作者:
[西村 理行, 波多 賢二, 高島利加子, 吉田倫子]
通讯作者:
吉田倫子
共 30 条
Establishment of a novel screening system to isolate PTH-like osteogenic small compounds
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批准号:24659824
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2012
-
负责人:NISHIMURA Riko
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依托单位:
Investigation for development of technique reprogramming of mesenchymal stem cells using epigenetic analyses
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批准号:22659336
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.18万
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财政年份:2010
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负责人:NISHIMURA Riko
-
依托单位:
Understanding of molecular basis by which Indian hedgehog signaling regulates osteoblast differentiation
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批准号:19390473
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.06万
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财政年份:2007
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负责人:NISHIMURA Riko
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依托单位:
Investigation of relationship between Osterix and Cbfal during BMP2-induced osteoblast differentiation
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批准号:15390560
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.19万
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财政年份:2003
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负责人:NISHIMURA Riko
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依托单位:
The Regulation of osteobiastogenesis and adipogenesis by BMP2
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批准号:12671804
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:2000
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负责人:NISHIMURA Riko
-
依托单位:
Role of Cytokines Signaling in Osteoblastic Differentiation
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批准号:10671739
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:1998
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负责人:NISHIMURA Riko
-
依托单位:
海外基金