Understanding of molecular basis by which Indian hedgehog signaling regulates osteoblast differentiation

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Indian hedgehog (Ihh) has been shown to play important roles in development of several tissues including skeletal tissues. In particular, Ihh conducts bone formation by regulating osteoblast and chondrocyte differentiation. In this study, to understand the mechanisms of Ihh, we investigated mechanisms and roles of Ihh signaling pathway. We found that Ihh controls expression and function of transcription factors, Gli family members, thereby regulating osteoblast differentiation. Furthermore, we demonstrated that Ihh signaling collaborates with Bone morphogenetic protein 2 (BMP2) signaling and Runx2, and that this cross-talk enhances osteoblast differentiation.