Clarification of implant loading condition on the basis of nanometer level structural analyses

骨在动态载荷的作用下进行重塑，导致骨数量和骨质量的适应。本研究的目的是阐明机械载荷对种植体周围骨整合和骨质量和数量的影响。骨整合、骨数量、骨密度和骨质量（由骨细胞数量和生物磷灰石（BAp） c轴/胶原纤维的优先排列定义）通过组织形态学分析、显微计算机断层扫描、偏振光显微镜和微束x射线衍射仪进行评估。起始时间、体积和重复载荷都有力地促进了骨整合和骨量。骨密度也有所增加。此外，种植体周围骨质量明显改善，骨细胞数量增加，BAp c轴/胶原纤维优先排列。

Bone is remodeled in response to dynamic loading, resulting in the adaptation of bone quantity and bone quality. The aims of this study were to clarify the effects of mechanical loading on osseointegration and bone quality and quantity around dental implants. Osseointegration, bone quantity, BMD, and bone quality, as defined by osteocyte numbers and the preferential alignment of biological apatite (BAp) c-axis/collagen fibers, were assessed using histomorphometric analyses, microcomputed tomography, polarized light microscopy and microbeam X-ray diffractometer. The time of initiation, the volume and the repetition of loading have vigorously enhanced osseointegration and bone quantity. BMD was also increased. Moreover, bone quality around dental implant was markedly improved with increased osteocyte numbers and preferential alignment of BAp c-axis/collagen fibers.