Effect of dental-plaque eco-system to caries-related genes in cariogenic mutans streptococci

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A result of examining the properties obtained from mutans streptococci (MS) and plaque in children showed that the ratio of MS in plaque related to caries severity nature of MS. Apparent difference was found in expression level of caries-related genes in the acidic environment in particular between high caries group and low-caries group. On the other hand, the tendency of plaque formation inhibition was observed in the Aml study of dental caries in the rat experimental model. The basic results of the (patent) clinical application was obtained revealed the plaque produce inhibitory effect on MS of Pamis extract from grape containing a large amount of oleanolic acid.