Jaw bone regeneration using gene activated matrix incorporated withdirectly prepared adipose derived stem cells
Jaw bone regeneration using gene activated matrix incorporated withdirectly prepared adipose derived stem cells
批准号:
22390387
负责人:
ASAHINA Izumi
金额:
$12.48万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Adipose derived stem cells (ADSCs) have been isolated from adipose tissue by the simple method with collagenase digestion and centrifugation. Direct implantation of freshly isolated ADSCs with minimal amount of BMP could induce ectopic bone formation. ADSCs transfected with the plasmid carrying BMP and/or Wnt genes differentiated into osteoblasts in vitro. Implantation of the gene activated matrix (GAM) consisted with atelocollagen, which constructed with BMP gene by calcium precipitation method, induced bone formation and the addition of ADSCs to the GAM accelerated the bone induction.
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自家抜去歯を使用する新しい骨移植材「Auto-Tooth Bone」
“自体牙骨”是一种利用自体拔除牙齿的新型骨移植材料。
DOI:
--
发表时间:
2011
期刊:
The Quintessence
影响因子:
--
作者:
[三次正春, 村田勝, In-Woong Um, 朝比奈泉, 楠川仁悟, 赤澤敬之]
通讯作者:
赤澤敬之
Growth/differentiation factors (GDFs) maintain tendongenic characteristics of human periodontal ligament-derived cells in culture
生长/分化因子 (GDF) 维持培养物中人牙周膜来源细胞的肌腱形成特征
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Sumita Y , Xia D, Wakamatsu Y, Kawasaki T, Liu Y, Maria OM, Khalili S, Agata H, Kagami H, Tran SD, Asahina I.]
通讯作者:
Asahina I.
細胞あるいは成長因子を用いた骨組織の再生
使用细胞或生长因子进行骨组织再生
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Sumita Y, Xia D, Wakamatsu Y, Kawasaki T, Liu Y, Maria O, Khalili S, Agata H, Kagami H, Tran SD, Asahina I, 日比英晴, 安保直樹, 朝比奈泉]
通讯作者:
朝比奈泉
重度低酸素条件による歯根膜由来細胞の選択的培養の試み
严重缺氧条件下选择性培养牙周膜来源细胞的尝试
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[川崎貴子, 住田吉慶, 縣秀樹, 各務秀明, 朝比奈泉]
通讯作者:
朝比奈泉
DOI:
10.1007/s10439-010-0115-2
发表时间:
2011-01-01
期刊:
ANNALS OF BIOMEDICAL ENGINEERING
影响因子:
3.8
作者:
[Ikeda, Hideyoshi, Sumita, Yoshinori, Asahina, Izumi]
通讯作者:
Asahina, Izumi
共 13 条
Development of gene-activated matrix with MSC-exosome for bone engineering
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批准号:16K15826
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.16万
-
财政年份:2016
-
负责人:ASAHINA Izumi
-
依托单位:
Delivery of functional microRNA accelerates the bone regeneration with BMP2 and BMAC.
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批准号:25670863
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2013
-
负责人:ASAHINA Izumi
-
依托单位:
Bone engineering with gene activated-matrix and non-cultured adipose cells
-
批准号:25293413
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.9万
-
财政年份:2013
-
负责人:ASAHINA Izumi
-
依托单位:
Development of stem cell therapy for the oral tissues damaged by chemo-radiation therapy
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批准号:23659952
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2011
-
负责人:ASAHINA Izumi
-
依托单位:
Hard Tissue Regeneration using Gene Activated Matrix
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批准号:13470429
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.96万
-
财政年份:2001
-
负责人:ASAHINA Izumi
-
依托单位:
ANALYSIS OF SIGNAL TRANSDUCTION PATHWAY IN BONE INDUCTION BY BONE MORPHOGENETIC PROTEIN
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批准号:09672039
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
-
财政年份:1997
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负责人:ASAHINA Izumi
-
依托单位:
DEVELOPMENT OF CELL HYBRID ARTIFICIAL BONE USING 3-D CELL CULTURE SYSTEM
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批准号:08557114
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$4.93万
-
财政年份:1996
-
负责人:ASAHINA Izumi
-
依托单位:
Analysis of Genes Induced by Bone Morphogenetic Protein (BMP) in the Early Stage of Response
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批准号:06807156
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1994
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负责人:ASAHINA Izumi
-
依托单位:
海外基金