Health effects of asbestos exposure with special reference to job type

石棉暴露对健康的影响，特别是对工作类型的影响

• 批准号: 22406018
• 负责人: YANO Eiji
• 金额: $ 12.56万
• 依托单位: Teikyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22406018/
• 关键词: 石綿; 肺がん; 喫煙; 死因別死亡率; 疫学研究; クリソタイル; アンフィボール; 石綿鉱山; 中国; 繊維種別; コホート研究; 胸膜悪性中皮腫; 相乗作用; 疫学

A cohort study for 37 years follow-up was undertaken in an asbestos textile plant in China, where only chrysotile had been used. Cox proportional hazard ratio (HR) of cause-specific mortality was estimated, while taking into account age, smoking, and asbestos exposure level. In asbestos workers, HRs for mortality by all causes, all cancers, lung cancer, and respiratory diseases were 2.05 (95% CI:1.56 to 2.68), 1.89 (1.25 to 2.87), 3.31(1.60 to 6.87), and 3.23 (1.68 to 6.22), respectively. By a case-control study within a cohort in the same plant, we found 5 times elevation of the incidence of lung cancer among high exposed non-smoking workers but it was 3 times for smokers with low asbestos exposure. However, it elevated to more than10 times when workers smoke and exposed to high level of asbestos, suggesting the synergistic effects of the two for lung cancer. Also in a chrysotile miners cohort in China, mortality by lung cancer and non-malignant pulmonary diseases were elevated.

一项长达37年的队列研究是在中国的一家石棉纺织厂进行的，该厂只使用过温石棉。在考虑了年龄、吸烟和石棉暴露水平的同时，估计了特定原因死亡率的COX比例风险比(HR)。石棉工人全死因、全癌、肺癌和呼吸系统疾病死亡的相对危险度分别为2.05(95%CI：1.56~2.68)、1.89(1.25~2.87)、3.31(1.60~6.87)和3.23(1.68~6.22)。通过同一工厂队列内的病例对照研究，我们发现，高暴露不吸烟工人的肺癌发病率是高暴露工人的5倍，而低石棉暴露的吸烟者是3倍。然而，当工人吸烟和暴露于高水平的石棉时，它会上升到10倍以上，这表明两者对肺癌的协同作用。在中国的一个温石棉矿工队列中，肺癌和非恶性肺部疾病的死亡率也有所上升。

项目成果

Lung cancer mortality from exposure to chrysotile asbestos and smoking: a case-control study within a cohort in China.

• DOI: 10.1136/oem.2009.051615
• 发表时间: 2010-12
• 期刊: Occupational and environmental medicine
• 影响因子: 4.9
• 作者: Yano E;Wang X;Wang M;Qiu H;Wang Z
• 通讯作者: Wang Z

Longitudinal Changes in Pulmonary Function of Asbestos Workers

• DOI: 10.1539/joh.l10062
• 发表时间: 2010-09
• 期刊: Journal of Occupational Health
• 影响因子: 3
• 作者: Xiaorong Wang;Mian-zhen Wang;H. Qiu;I. Yu;E. Yano

疫学から見たアスベスト関連疾患ー中国における調査からー

从流行病学角度看石棉相关疾病 - 来自中国的调查 -

• 发表时间: 2012
• 作者: Ghosh S;Shintani T;Kobayashi N;矢野栄二
• 通讯作者: 矢野栄二

A 37-year observation of mortality in Chinese chrysotile asbestos workers

• DOI: 10.1136/thoraxjnl-2011-200169
• 发表时间: 2011-09
• 期刊: Thorax
• 影响因子: 10
• 作者: Xiaorong Wang;E. Yano;H. Qiu;I. Yu;Midori N. Courtice;L. Tse;Sihao Lin;Mian-zhen Wang

Mortality in a Chinese chrysotile miner cohort

中国温石棉矿工群体的死亡率

• DOI: 10.1007/s00420-011-0685-9
• 发表时间: 2012
• 期刊: Int Arch Occup Environ Health
• 作者: Wang X;Lin S;Yano E;Qiu H;Yu IT;Tse L;Lan Y;Wang M
• 通讯作者: Wang M