Cohort study of asbestos workers with special reference to type, size, and number of exposed fiber.

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By a case-control study within a cohort of an asbestos plant in China, we found 5 times elevation of the incidence of lung cancer among high exposed non-smoking workers but it was 3 times for smokers with low asbestos exposure. However, it elevated to more than10 times when workers smoke and exposed to high level of asbestos suggesting the synergistic effects of the two for lung cancer. In the lung tissue of a male mesothelioma case, chrysotile was seldom found, whereas vast majority was tremolite which scarcely existed in the low material.