Modulatory effects ofperineuronalglial cells on neuronal activities of pyramidal cells

周围神经胶质细胞对锥体细胞神经元活动的调节作用

• 批准号: 22500352
• 负责人: YAMAZAKI Yoshihiko
• 金额: $ 2.58万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500352/
• 关键词: 海馬; グリア; 錐体細胞; 活動電位; 発火周波数; CA1; グリア細胞; 静止膜電位

We identified perineuronal glial cells (PNG) of pyramidal cells in CA1 region of the rat hippocampus. The maximum firing frequency of the pyramidal cells accompanying the PNG was significantly smaller than that of the pyramidal cells without PNG. Direct depolarization of PNG increased the firing frequency of action potentials of pyramidal cells, especially in the initial phase of the depolarization. These results indicate that the PNG modulate the activity of pyramidal cells constitutively and activity-dependently.

我们在大鼠海马CA1区发现了锥体细胞的神经周围神经胶质细胞(PNG)。伴有PNG的锥体细胞的最大放电频率明显小于未伴有PNG的锥体细胞。PNG直接去极化可增加锥体细胞动作电位的放电频率，尤其是在去极化初期。这些结果表明，PNG对锥体细胞的活性具有结构性和活性依赖性的调节作用。

项目成果

Properties of perineuronal oligodendrocytes and its modulatory effects on neuronal activities in CA1 region of rat hippocampus

神经周少突胶质细胞的特性及其对大鼠海马CA1区神经元活动的调节作用

• 发表时间: 2010
• 作者: 山崎良彦;Yamazaki Y.
• 通讯作者: Yamazaki Y.

Nicotine facilitates long-term potentiation induction in oriens-lacunosum moleculare cells via Ca2+ entry through non-alpha7 nicotinic acetylcholine receptors.

• DOI: 10.1111/j.1460-9568.2009.07058.x
• 发表时间: 2010-02
• 期刊: The European journal of neuroscience
• 作者: Jia Y;Yamazaki Y;Nakauchi S;Ito K;Sumikawa K
• 通讯作者: Sumikawa K

Oligodendrocyte dysfunction hypothesis in schizophrenia and beyond

精神分裂症及其他疾病的少突胶质细胞功能障碍假说

• 发表时间: 2012
• 作者: Tanaka K;Yamazaki Y;et al.
• 通讯作者: et al.

Intracellular calcium ion dynamics involved in long-term potentiation in hippocampal CA1 neurons in mice lacking the IP3 type 1 receptor

• DOI: 10.1016/j.neures.2010.03.002
• 发表时间: 2010-06
• 期刊: Neuroscience Research
• 影响因子: 2.9
• 作者: M. Yoshioka;Y. Yamazaki;S. Fujii;K. Kaneko;H. Kato;K. Mikoshiba

Modulatory effects of peri-interneuronal oligodendrocyte on interneuronal firing inCA1 region of rat hippocampus

周围神经元少突胶质细胞对大鼠海马CA1区神经元间放电的调节作用

• 发表时间: 2012
• 作者: Yamazaki Y;et al.
• 通讯作者: et al.