Modulatory effects ofperineuronalglial cells on neuronal activities of pyramidal cells

我们在大鼠海马CA1区发现了锥体细胞的神经周围神经胶质细胞(PNG)。伴有PNG的锥体细胞的最大放电频率明显小于未伴有PNG的锥体细胞。PNG直接去极化可增加锥体细胞动作电位的放电频率，尤其是在去极化初期。这些结果表明，PNG对锥体细胞的活性具有结构性和活性依赖性的调节作用。

We identified perineuronal glial cells (PNG) of pyramidal cells in CA1 region of the rat hippocampus. The maximum firing frequency of the pyramidal cells accompanying the PNG was significantly smaller than that of the pyramidal cells without PNG. Direct depolarization of PNG increased the firing frequency of action potentials of pyramidal cells, especially in the initial phase of the depolarization. These results indicate that the PNG modulate the activity of pyramidal cells constitutively and activity-dependently.