Modulatory effects of oligodendrocytes on axonal conduction of action potentials

海马齿状突内的少突胶质细胞对外源性谷氨酸受体有去极化反应。电刺激通过谷氨酸受体和内向整流钾通道等多种途径诱发内向电流。少突胶质细胞的直接去极化缩短了动作电位的潜伏期，表明少突胶质细胞除跳跃传导外，还通过另一种机制加快动作电位的传导速度，在脑信息处理中发挥积极作用。

Oligodendrocytes in the alveus of hippocampus were found to respond to exogenously applied glutamate receptors with depolarization. Electrical stimulation evoked inward currents through various routes involving glutamate receptors and inward rectifier potassium channels. Direct depolarization of oligodendrocytes shortened the latencies of action potentials, indicating that oligodendrocytes increase the conduction velocity of action potentials by another mechanism in addition to saltatory conduction and play active roles in information processing in the brain.