Improvement of peripheral microcirculation by a new gas transmitter delivery

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We investigated roles of hydrogen sulfide (HS) in the regulation of the microcirculatory system. L-cysteine (a substrate of H2S) caused endothelium-independent dilations of the arterioles through an activation of cystathionineγ-lyase (CSE) located on the arteriolar smooth muscles. L-cysteine reduced frequency of pumping activity in isolated rat collecting lymphatics. The L-cysteine-mediated negative chronotropic effects of the lymphatics were converted into positive chronotropism in the presence of DL-propargylglycine（PAG; a selective inhibitor of CSE. These results indicate that L-cysteine-CSE-HS pathway plays significant roles in the regulation of the microcirculatory system including arterioles and collecting lymphatics.