Investigation for mechanisms of "resistance to lipid" in skeletal muscle

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The accumulation of intramyocellular lipid (IMCL) is regarded to be a cause of insulin resistance. On the other hand, increased accumulation of IMCL is also observed in insulin sensitive subjects (resistance to lipids). Thus, we aimed to clarify the mechanisms of the phenomenon. The IMCL levels were measured by 1H-magnetic resonance spectroscopy (MRS) and peripheral insulin sensitivity (GIR) was evaluated by clamp study. Muscle biopsy sample was obtained from vastus lateralis. Resistance to lipids is associated with increased expression level of lipid oxidation and uptake genes in skeletal muscle. These gene expressions may intermediate IMCL accumulation and insulin sensitivity.