Mechanism how pigpen, a nuclear protein induces angiogenesis and the application for the control of angiogenesis

当作者研究PILSAP时，我们发现它既是一种血管生成因子，也是一种血管生成因子，一种核蛋白Pigpen被认为在那里起着一定的作用。siRNA对Pigpen表达的抑制表明，Pigpen参与了血管生成和血管生成。此外，VEGF（血管内皮生长因子）通过动员PILSAP从细胞质到细胞核，增加了PILSAP-猪圈复合物的形成。我们的研究表明，PILSAP可能与猪圈协同诱导血管生成和血管生成

While the authors investigated how PILSAP, which we found as an angiogenic factor as well as a vasculogenic one, a nuclear protein Pigpen was thought to play a certain role there. The inhibition of Pigpen expression by siRNA showed that pigpen was involved in angiogenesis and vasculogenesis. Moreover, VEGF (vascular endothelial growth factor) increased PILSAP-pigpen complex formation by mobilization of PILSAP from cytoplasm to nucleus. Our study demonstrates that PILSAP may cooperate with pigpen to induce angiogenesis and vasculogenesis