Potential role of Mieap, a p53-inducible protein, in tumor suppression and mitochondrial quality control

Mieap是一种p53诱导蛋白，通过MALM（Mieap诱导的线粒体内溶酶体样细胞器的积累：氧化线粒体蛋白的消除）或MIV（Mieap诱导的空泡：不健康线粒体的降解）修复或消除不健康的线粒体来控制线粒体质量。在人类癌细胞中，该功能经常失活，导致不健康线粒体的积累和线粒体产生的活性氧（ROS）增加。线粒体活性氧在肿瘤的发生、发展、侵袭和转移中起着重要作用。

Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria via MALM (the Mieap-induced accumulation of lysosome-like organelles within mitochondria: the elimination of oxidized mitochondrial proteins) or MIV (Mieap-induced vacuole: the degradation of unhealthy mitochodria). In human cancer cells, the function is frequently inactivated, leading to the accumulation of unhealthy mitochondria and increase of reactive oxygen species (ROS) production by the mitochondria. The mitochondrial ROS may play a critical role in cancer initiation, progression, invasion and metastasis.