Study on the Metabolic Syndrome in Japanese Living in Japan and Hawaii for Prevention of Atherosclerotic Disease.

研究居住在日本和夏威夷的日本人的代谢综合征以预防动脉粥样硬化疾病。

基本信息

批准号：
17590563
负责人：
NAKAMURA Yasuyuki
金额：
$ 2.3万
依托单位：
Kyoto Women's University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

项目摘要

Backgrounds : A novel adipose-specific protein, adiponectin has been suggested to play an important role in modulation of the metabolic syndrome (MetSx). We compared the prevalence of MetSx and the plasma adiponectin concentrations among Japanese men and women in Japan and Hawaii.Methods : In between 1997 and 1998, community-based men and women aged 40-59 years were examined by common standardized methods-a sample in Japan (130 men and 129 women) and a Japanese-American sample in Hawaii (136 men and 131 women).MetSx was defined as the co-occurrence of any 3 or more of the following 5 abnormalities: body mass index (BMI) > 30 kg/m2, HbA1c > 5.6%, blood pressure 130/85 mmHg or use of antihypertensive therapy, triglycerides greater than or equal 150 mg/dl, HDLc < 40 mg/dl.Results : The mean BMI was higher in those who live in Hawaii than those in Japan (men: 23.4±2.8 vs 28.1±4.7 kg/m2, P<0.0001; women: 23.4±3.0 vs 25.9±5.4 kg/m2, P<0.0001). The prevalence of MetSx was higher in those who live in Hawaii than those in Japan (men: 3.9% vs 23.2%, P<0.0001; women: 2.3% vs 9.7%, P=0.012)The mean adiponectin was higher in those who live in Japan (men: 8.1±3.8 vs 6.7±3.2 μg/ml, P=0.003; women 12.9±6.1 vs 9.3±4.2 μg/ml, P<0.0001), however, the difference was not significant among those with BMI > 28 kg/m2 (P=0.16 for men and P=0.40 for women). Significant determinants of adiponectin were BMI, HDLc and Alcohol consumption in men, and Age, BMI, Site, HDLc, and Energy intake in women.Conclusions : BMI has a significant effect on MetSx and adiponectin in Japanese.

背景：一种新型的脂肪特异性蛋白，脂联素被认为在调节代谢综合征（METSX）中起着重要作用。我们比较了日本和夏威夷的日本男性和女性中METSX和血浆脂结蛋白浓度的普遍性。方法：在1997年至1998年之间，在日本的常见标准化方法中，以社区为基础的男性和40-59岁的男性和女性在日本的样本中进行了样本 - 日本（130名男性和129名男性和129名男性），以及在Hawaii和136 Men和136 Mentiment of Spectim of Specters and Spectiment and Specrient at hawaii（136 Men）。 of any 3 or more of the following 5 abnormalities: body mass index (BMI) > 30 kg/m2, HbA1c > 5.6%, blood pressure 130/85 mmHg or use of antihypertensive therapy, triglycerides greater than or equal 150 mg/dl, HDLc < 40 mg/dl.Results : The mean BMI was higher in those who live in Hawaii than those in Japan (men: 23.4±2.8 vs 28.1±4.7 kg/m2，p <0.0001：23.4±3.0 vs 25.9±5.4 kg/m2，p <0.0001）。居住在夏威夷人的METSX的患病率高于日本（男性：3.9％vs 23.2％，p <0.0001；女性：2.3％：2.3％vs 9.7％，p = 0.012）居住在日本的人的平均脂连蛋白更高（男性：8.1±3.8 vs 6.7±3.8±3.2±3.2±3.2μg/ml，p = 0.9 vs;但是，在BMI> 28 kg/m2的患者中，差异并不显着（男性p = 0.16，女性p = 0.40）。脂联素的重要决定素是男性，男性，年龄，BMI，现场，HDLC和能量摄入量的BMI，HDLC和饮酒。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Combined Cardiovascular Risk Factors and Outcome : NIPPON DATA80, 1980-94.

综合心血管危险因素和结果：NIPPON DATA80，1980-94。

DOI：
发表时间：
2006
期刊：
Circ J 70・8
影响因子：
0
作者：
S. Inoue;et. al.;Nakamura Y(1)他8名
通讯作者：
Nakamura Y(1)他8名

Relationship between the metabolic syndrome and Trp64Arg polymorphism of the s3 adrenergic receptor gene in a general sample (The Shigaraki Study)

一般样本中代谢综合征与 s3 肾上腺素受体基因 Trp64Arg 多态性之间的关系（信乐研究）

DOI：
发表时间：
2006
期刊：
Hyperten Res 29・11
影响因子：
0
作者：
Tamaki S(1);Nakamura Y(2)他8名
通讯作者：
Nakamura Y(2)他8名

Combined Cardiovascular Risk Factors and Outcome

综合心血管危险因素和结果

DOI：
发表时间：
2006
期刊：
NIPPON DATA80 1980-1994
影响因子：
0
作者：
Nakamura Y;Yamamoto T;Okamura T;Kadowaki T;Hayakawa T;Kita Y;Saitoh S;Okayama A;Ueshima H.
通讯作者：
Ueshima H.

Combined analysis of polymorphisms in angiotensionogen and adducin genes and their effects on hypertension in a Japanese sample : The Shigaraki Study.

日本样本中血管紧张素和内收蛋白基因多态性的联合分析及其对高血压的影响：信乐研究。