Study on the Metabolic Syndrome in Japanese Living in Japan and Hawaii for Prevention of Atherosclerotic Disease.

研究居住在日本和夏威夷的日本人的代谢综合征以预防动脉粥样硬化疾病。

• 批准号: 17590563
• 负责人: NAKAMURA Yasuyuki
• 金额: $ 2.3万
• 依托单位: Kyoto Women's University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590563/
• 关键词: The Metabolic Syndrome; Adiponectin; Japanese American in Hawaii; Obesity; Community-based Population; Epidemiology; アディポネチン

Backgrounds : A novel adipose-specific protein, adiponectin has been suggested to play an important role in modulation of the metabolic syndrome (MetSx). We compared the prevalence of MetSx and the plasma adiponectin concentrations among Japanese men and women in Japan and Hawaii.Methods : In between 1997 and 1998, community-based men and women aged 40-59 years were examined by common standardized methods-a sample in Japan (130 men and 129 women) and a Japanese-American sample in Hawaii (136 men and 131 women).MetSx was defined as the co-occurrence of any 3 or more of the following 5 abnormalities: body mass index (BMI) > 30 kg/m2, HbA1c > 5.6%, blood pressure 130/85 mmHg or use of antihypertensive therapy, triglycerides greater than or equal 150 mg/dl, HDLc < 40 mg/dl.Results : The mean BMI was higher in those who live in Hawaii than those in Japan (men: 23.4±2.8 vs 28.1±4.7 kg/m2, P<0.0001; women: 23.4±3.0 vs 25.9±5.4 kg/m2, P<0.0001). The prevalence of MetSx was higher in those who live in Hawaii than those in Japan (men: 3.9% vs 23.2%, P<0.0001; women: 2.3% vs 9.7%, P=0.012)The mean adiponectin was higher in those who live in Japan (men: 8.1±3.8 vs 6.7±3.2 μg/ml, P=0.003; women 12.9±6.1 vs 9.3±4.2 μg/ml, P<0.0001), however, the difference was not significant among those with BMI > 28 kg/m2 (P=0.16 for men and P=0.40 for women). Significant determinants of adiponectin were BMI, HDLc and Alcohol consumption in men, and Age, BMI, Site, HDLc, and Energy intake in women.Conclusions : BMI has a significant effect on MetSx and adiponectin in Japanese.

背景资料：脂联素是一种新的脂肪特异性蛋白，在代谢综合征（MetSx）的调节中起重要作用。我们比较了在日本和夏威夷的日本男性和女性的MetSx患病率和血浆脂联素浓度。1997年至1998年间，以社区为基础的男性和女性，年龄在40-59岁，进行了检查，共同的标准化方法，在日本的样本（130名男性和129名女性）和一个在夏威夷的日裔美国人样本（136名男性和131名女性）JetSx被定义为以下5种异常中的任何3种或更多种的共同发生：体重指数（BMI）> 30 kg/m2，HbA 1c> 5.6%，血压130/85 mmHg或使用抗高血压药物，甘油三酯≥ 150 mg/dl，HDLc < 40 mg/dl（男性：23.4±2.8 vs 28.1±4.7 kg/m2，P<0.0001;女性：23.4±3.0 vs 25.9±5.4 kg/m2，P<0.0001）。居住在夏威夷的人MetSx的患病率高于居住在日本的人（男性：3.9% vs 23.2%，P<0.0001;女性：2.3% vs 9.7%，P=0.012）居住在日本的人的平均脂联素水平较高（男性：8.1±3.8 vs 6.7±3.2 μg/ml，P=0.003;女性：12.9±6.1 vs 9.3±4.2 μg/ml，P<0.0001），但在BMI > 28 kg/m2的人群中差异无统计学意义（男性P=0.16，女性P=0.40）。脂联素的显着决定因素是BMI，高密度脂蛋白C和男性的酒精消费量，年龄，BMI，网站，高密度脂蛋白C，和能量intake in women.Conclusions：BMI对MetSx和脂联素在日本有显着影响。

项目成果

Combined Cardiovascular Risk Factors and Outcome : NIPPON DATA80, 1980-94.

综合心血管危险因素和结果：NIPPON DATA80，1980-94。

• 发表时间: 2006
• 期刊: Circ J 70・8
• 作者: S. Inoue;et. al.;Nakamura Y(1)他8名
• 通讯作者: Nakamura Y(1)他8名

The relationship between serum total cholesterol and all-cause or cause-specific mortality in a 17.3-year study of a Japanese cohort

• DOI: 10.1016/j.atherosclerosis.2006.01.024
• 发表时间: 2007-01-01
• 期刊: ATHEROSCLEROSIS
• 影响因子: 5.3
• 作者: Okamura, Tomonori;Tanaka, Hideo;Ueshima, Hirotsugu
• 通讯作者: Ueshima, Hirotsugu

Combined analysis of polymorphisms in angiotensionogen and adducin genes and their effects on hypertension in a Japanese sample : The Shigaraki Study.

日本样本中血管紧张素和内收蛋白基因多态性的联合分析及其对高血压的影响：信乐研究。

• 发表时间: 2005
• 期刊: Hypertens Res 28(8)
• 作者: Tamaki S;Nakamura Y他8名
• 通讯作者: Nakamura Y他8名

The Associations of Obesity Measures with the Metabolic Risk Factors in a Community-based Population in Japan. 2007; 71 :.

日本社区人群肥胖测量与代谢风险因素的关联。

• 发表时间: 2007
• 期刊: Circ J 71・5
• 作者: Ohshige K;Hori Y;Tochikubo 0;Sugiyama M.;Nakamura Y (1) 他8名
• 通讯作者: Nakamura Y (1) 他8名

Egg consumption, serum total cholesterol concentrations and coronary heart disease incidence: Japan Public Health Center-based prospective study

• DOI: 10.1017/bjn20061937
• 发表时间: 2006-11
• 期刊: British Journal of Nutrition
• 影响因子: 3.6
• 作者: Yasuyuki Nakamura;H. Iso;Y. Kita;H. Ueshima;K. Okada;M. Konishi;M. Inoue;S. Tsugane