Relation of leptin and adiponectin to subclinical atherosclerosis

瘦素、脂联素与亚临床动脉粥样硬化的关系

• 批准号: 23590823
• 负责人: NAKAMURA Yasuyuki
• 金额: $ 3.41万
• 依托单位: Kyoto Women's University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590823/
• 关键词: 潜在的動脈硬化; レプチン; アディポネクチン; 冠動脈石灰化; 頸動脈内膜-中膜肥厚; 頸動脈内膜-中膜肥厚度; 頸動脈内中膜肥厚; 潜在性動脈硬化; 疫学研究

Mean intima-media thickness (IMT), and Agaston score were significantly greater in the higher leptin concentration groups, and were significantly lower in the higher adiponectin concentration groups. In multiple linear regression models adjusted for confounders, log-leptin and log-adiponectin did not relate to IMT. In logistic regression models adjusted for age, log-leptin was significantly directly related to CAC (Agaston score>=10), but significantly inversely related to CAC in a model adjusted for multiple confounders. Log-adiponectin did not relate to CAC.Log-leptin was significantly directly related to CAC in an age-adjusted model, but was significantly inversely related to CAC in a multivariable adjusted model. The inverse relation of leptin to CAC in multivariable analysis in this study may support clinical use of leptin in weight reduction.

在较高的瘦素浓度组中，平均内膜膜厚度（IMT）和AGASTON评分明显更高，并且在较高的脂联素浓度组中显着较低。在针对混杂因素调整的多个线性回归模型中，log-leptin和log-adiponectin与IMT无关。在针对年龄调整的逻辑回归模型中，log-Leptin与CAC（Agaston得分> = 10）显着直接相关，但与针对多个混杂因素调整的模型中的CAC显着相关。在年龄调整的模型中，log-diponectin与CAC-Log-Leptin与CAC无关，但在多变量调整的模型中与CAC显着相关。在这项研究中，瘦素与CAC的逆关系可能支持瘦素减轻体重的临床使用。

项目成果

Significant Inverse Association of Serum Docosahexaenoic Acid with Coronary Artery Calcification Among Men in the General Population in Japan

日本普通人群中男性血清二十二碳六烯酸与冠状动脉钙化呈显着负相关

• 发表时间: 2013
• 作者: Sekikawa A;Miura K;Nakamura Y;Ueshima H;et al
• 通讯作者: et al

Research Group. Relation of dietary and lifestyle traits to difference in serum leptin of Japanese in Japan and Hawaii: The INTERLIPID study

研究组。

• 发表时间: 2012
• 期刊: Nutr Metab Cardiovasc Dis
• 作者: 116.Nakamura Y;Ueshima H;Okuda N;Miura K;Kita Y;Okamura T;Turin TC;Okayama A;Rodriguez B;Curb JD;Stamler J
• 通讯作者: Stamler J

Fatty acids intakes and coronary heart disease mortality in Japan : NIPPON DATA90, 1990-2005

日本的脂肪酸摄入量和冠心病死亡率：NIPPON DATA90，1990-2005

• 发表时间: 2012
• 作者: Nakamura Y;Miura K;Ueshima H;et al
• 通讯作者: et al

Relation of Serum Leptin and Adiponectin Level to Serum C-Reactive Protein of Japanese in Japan and Japanese-Americans in Hawaii : The INTERLIPID Study

日本人和夏威夷日裔美国人血清瘦素和脂联素水平与血清​​ C 反应蛋白的关系：INTERLIPID 研究

• 发表时间: 2013
• 作者: Nakamura Y;Ueshima H;Okuda N;Miura K;et al
• 通讯作者: et al

Relationship between health-related quality of life and clustering of metabolic syndrome diagnostic components

• DOI: 10.1007/s11136-011-0029-y
• 发表时间: 2012-09-01
• 期刊: QUALITY OF LIFE RESEARCH
• 影响因子: 3.5
• 作者: Katano, Sayuri;Nakamura, Yasuyuki;Ueshima, Hirotsugu
• 通讯作者: Ueshima, Hirotsugu