Development of novel bioactive organo-medicinal compounds against metabolic syndrome

最近，Asano等从风铃草和葡萄风信子中分离出一系列新的风信子碱，这些化合物以可逆和竞争的方式强烈抑制各种糖苷酶。虽然最近有几个小组完成了风信子碱A系列的许多全合成，但风信子碱B和C系列的合成迄今尚未实现。本报告的中心特征是描述了从（S）-2-吡咯烷酮-5-羧酸开始立体选择性构建风信子碱B1、B2、C2和C3的第一条快速路线的细节。

Recently a new series of hyacinthacines were isolated from bluebells and grape hyacinths by Asano et al. These compounds strongly inhibit various glycosidases in a reversible and competitive manner. While many total syntheses of hyacinthacine A series have been recently completed by several groups, the synthesis of hyacinthacine B and C series, however, has not been achieved to date. The central feature of this report is to describe the details of the first and expeditious route for the stereoselective construction of hyacinthacine B1, B2, C2, and C3 starting from (S)-2-pyrrolidone-5-carboxylic acid.